ArticleACS omega2026
Pluronic F127 Micelles Co-encapsulating a Brachydin-Enriched Fraction and Curcumin: A Self-assembled Platform for Light-assisted Antileishmanial Activity.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
This study developed an associative Pluronic F127-based formulation co-loaded with a brachydin-enriched fraction and curcumin (FBC) for preliminary light-assisted antileishmanial evaluation. The formulation showed high apparent active-material recovery after centrifugation and filtration, as estimated by HPLC-PDA. DLS analysis indicated a polydisperse colloidal profile, with an apparent mean hydrodynamic diameter of approximately 406.5 nm and a number-weighted smaller population centered at approximately 12.1 nm. FTIR data were consistent with formulation-related changes in the vibrational environment of the hydrophobic active materials, while AFM and SEM provided complementary morphological information on deposited or dried samples. Together, these data support an interpretative F127-based self-assembly model, without establishing a fully uniform colloidal population or a definitively resolved internal micellar architecture. In vitro cytotoxicity assays using GM07492A human lung fibroblasts indicated low basal cytotoxicity under dark conditions, whereas light exposure produced concentration-dependent viability reductions at higher formulation concentrations. Antileishmanial assays against
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Registered trials
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