Evidence map›Paper›PMID 42889562›Full record

ArticleACS omega2026

A pH-Dependent Curcumin-Iminosugar Hybrid Promotes GCase Enhancement and Reactive Oxygen Species Reduction.

Alessio Morano, Camilla Matassini, Francesca Cardona, Damiano Tanini, Silvia Falliano, Amelia Morrone, Rebecca Sodano, Paolo Paoli, Andrea Goti, Francesca Clemente

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessio MoranoDepartment of Chemistry "Ugo Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, Sesto F.no (FI) 50019, Italy.
Camilla MatassiniDepartment of Chemistry "Ugo Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, Sesto F.no (FI) 50019, Italy.ORCID https://orcid.org/0000-0002-8336-383X
Francesca CardonaDepartment of Chemistry "Ugo Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, Sesto F.no (FI) 50019, Italy.ORCID https://orcid.org/0000-0002-6766-4624
Damiano TaniniDepartment of Chemistry "Ugo Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, Sesto F.no (FI) 50019, Italy.ORCID https://orcid.org/0000-0001-8930-3566
Silvia FallianoLaboratory of Molecular Genetics of Neurometabolic Diseases, Department of Neuroscience and Medical Genetics, Meyer Children's Hospital IRCCS, Viale Pieraccini 24, Firenze 50139, Italy.
Amelia MorroneLaboratory of Molecular Genetics of Neurometabolic Diseases, Department of Neuroscience and Medical Genetics, Meyer Children's Hospital IRCCS, Viale Pieraccini 24, Firenze 50139, Italy.ORCID https://orcid.org/0000-0003-2890-8179
Rebecca SodanoDepartment of Experimental and Clinical Biomedical Sciences (DSBSC), University of Florence, Viale Morgagni 50, Firenze 50134 Italy.ORCID https://orcid.org/0009-0005-7819-1796
Paolo PaoliDepartment of Experimental and Clinical Biomedical Sciences (DSBSC), University of Florence, Viale Morgagni 50, Firenze 50134 Italy.ORCID https://orcid.org/0000-0001-6448-7266
Andrea GotiDepartment of Chemistry "Ugo Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, Sesto F.no (FI) 50019, Italy.ORCID https://orcid.org/0000-0002-1081-533X
Francesca ClementeDepartment of Chemistry "Ugo Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, Sesto F.no (FI) 50019, Italy.ORCID https://orcid.org/0000-0002-9899-0836

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gaucher disease and Parkinson's disease are characterized by β-glucocerebrosidase (GCase) dysfunction and increased oxidative stress. Here, we report two multifunctional hybrids that combine an iminosugar-based pharmacological chaperone scaffold with curcumin- or ferulic acid-derived antioxidant motifs. The curcumin-iminosugar hybrid

Identifiers

PMID42889562
PMCPMC13670301

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.