ArticleNutrition research and practice2026
Association of stress-related genetic risk and lifestyle factors with BMI in Korean adults.
Article in Nutrition research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesGenetic susceptibility to stress may influence behavioral and metabolic responses involved in dietary choices and body weight regulation. While previous studies have focused on individual genetic variants related to dietary intake and obesity risk, a polygenic approach integrating multiple stress-related single nucleotide polymorphisms may better capture overall genetic susceptibility to stress. This study examined the relationship among stress-related polygenic risk, dietary intake, serum metabolite profiles, and body weight, and determined whether this relationship could be influenced by sleep duration and physical activity (PA). SUBJECTS/
methodsThis study included 100 disease-free participants with a body mass index (BMI) of 18.5 to 25.0 kg/m
resultsSerum cortisol concentration was significantly higher in the Risk GS
conclusionThis study demonstrated that individuals with a higher genetic risk for stress exhibited elevated cortisol levels and were associated with greater SSB intake and higher BMI. This relationship was more pronounced in those with insufficient sleep, emphasizing the importance of lifestyle factors in mitigating the effect of genetic stress risk on body weight. Trial Registration: Clinical Research Information Service Identifier: KCT0004650.
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