ReviewJournal of dental anesthesia and pain medicine2026
Nonsteroidal anti-inflammatory drug (NSAID) premedication for pain-free inferior alveolar nerve block: a systematic review and meta-analysis.
Review in Journal of dental anesthesia and pain medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
This systematic review and meta-analysis evaluated whether oral nonsteroidal anti-inflammatory drug (NSAID) premedication increases pain-free inferior alveolar nerve block (IANB) success compared with placebo in adults with mandibular posterior teeth diagnosed with symptomatic irreversible pulpitis (SIP). Randomized controlled trials comparing oral NSAID premedication with placebo before IANB in adults with mandibular posterior teeth and SIP were included. MEDLINE, Embase, Web of Science, and the Cochrane Library were searched from inception to October 20, 2025. This review was registered in PROSPERO (CRD420251171592). Success required absence of patient-reported intraoperative pain at any recorded procedural step after the initial IANB and no supplemental anesthesia. Risk of bias was assessed using RoB 2, certainty of evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation, and pooled effects were assessed using random-effects meta-analysis. Eleven trials involving 737 participants were analyzed. Oral NSAID premedication increased pain-free IANB success compared with placebo (292/452 [64.6%] vs 81/285 [28.4%]; risk ratio, 2.06; 95% confidence interval, 1.48-2.86). Heterogeneity was substantial (I
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