ReviewJournal of dental anesthesia and pain medicine2026
Effectiveness of NSAIDs premedication following third molar extraction: a systematic review with meta-analysis of randomized clinical trials.
Review in Journal of dental anesthesia and pain medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Third molar extraction is one of the most common procedures in oral surgery and is frequently associated with postoperative pain, edema, and trismus. In this context, this systematic review aimed to evaluate the effectiveness of premedication with non-steroidal anti-inflammatory drugs (NSAIDs) on postoperative outcomes following this procedure. A systematic review was conducted in accordance with the Cochrane guidelines and the PRISMA statement, with the protocol registered in PROSPERO (CRD420251048164). Randomized controlled trials including healthy adults undergoing third molar extraction under local anesthesia were included. NSAID premedication was compared with placebo or no premedication, with both groups following standardized postoperative rescue medication protocols. Searches were performed in PubMed, Embase, Web of Science, and EBSCO from inception to April 2025. The risk of bias was assessed using the Cochrane RoB-1 tool, and the certainty of the evidence was evaluated using the GRADE approach. Random-effects meta-analyses were conducted using standardized mean differences (SMD) and risk ratios (RR). Fifteen randomized controlled trials involving 779 participants were included. NSAID premedication significantly reduced postoperative pain within the first 4 h (SMD = -1.20), between 5 and 12 h (SMD = -0.75), at 24 h (SMD = -1.42), and at the longest follow-up periods (SMD = -1.25). It also reduced rescue medication consumption (SMD = -0.63) and the risk of rescue medication use by 39% (RR = 0.61). NSAID premedication reduces postoperative pain and the need for rescue medication after third molar extraction, with a favorable safety profile, supporting its clinical use despite the low certainty of the evidence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.