ArticleFrontiers in immunology2026
Single-cell mass cytometry cartography highlights systemic lupus erythematosus and Sjögren's disease immune differences.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Autoimmune diseases such as primary Sjögren's disease (pSjD) and systemic lupus erythematosus (SLE) share clinical and serological features, including type I interferon signatures, autoantibody formation, and chronic inflammation, but the underlying immunopathology is not the same. To support the development of targeted therapies, we aimed to systematically characterize disease-specific alterations in peripheral immune cell subsets of pSjD and SLE compared to healthy donors (HD). Methods: We analyzed peripheral blood mononuclear cells from 15 HD, 12 pSjD and 21 SLE patients by mass cytometry. We manually pre-gated viable CD19 Results: In the B cell compartment, we identified 13 clusters. SLE patients showed an relative expansion of plasmablasts and two double-negative (IgD Conclusion: SLE is characterized by B cell activation, plasmablast expansion, and costimulatory upregulation, while pSjD is mainly defined by alterations in the CD8
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