ArticleFrontiers in public health2026
Potential association between dementia polygenic risk scores and subjective cognitive burden in a post-COVID cohort: a hypothesis-generating study.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Coronavirus disease 2019 (COVID-19) may be associated with persistent subjective cognitive complaints, including difficulties with attention, memory, and executive function, in some individuals with post-acute sequelae of SARS-CoV-2 infection (PASC, "long COVID"). Inter-individual variability raises the possibility that host genetic factors contribute to susceptibility. This study explored the relationship between dementia-related polygenic risk scores (PRS) and subjective cognitive burden after COVID-19. Methods: Genome-wide genotype data from 60 individuals with a history of COVID-19 were merged with 915 South Asian population reference samples (total Results: COVID-19-affected individuals aged 18-52 years showed a modest rightward shift in dementia-related PRS compared with population reference samples, with substantial overlap between groups (mean standardized PRS 0.24 vs. - 0.01; Mann-Whitney U = 29,504.5, Conclusion: This hypothesis-generating study identified a possible relationship between dementia-related genetic liability and subjective cognitive burden after COVID-19. The PRS group comparison was descriptive and should not be interpreted as evidence of increased dementia risk. The phenotype-genotype finding is severely limited by the small subgroup, possible selection bias, non-validated subjective assessment, lack of multivariable adjustment, and cross-sectional design. Validation in larger, ancestry-matched, longitudinal cohorts is required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.