ArticleFrontiers in drug delivery2026
Design and optimization of mucoadhesive chitosan microspheres for oesophageal delivery of fluconazole.
Article in Frontiers in drug delivery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oesophageal candidiasis remains challenging to treat owing to rapid transit of conventional oral formulations through the oesophagus, resulting in inadequate local drug delivery and reduced therapeutic efficacy. To address these limitations, the present study aimed to develop fluconazole-loaded chitosan microspheres (FCZ-CMs)-based orodispersible tablets (ODTs) that rapidly disintegrate in the oral cavity while releasing mucoadhesive microspheres capable of adhering to oesophageal mucosa, enabling sustained localized drug delivery. Methods: FCZ-CMs were developed by the emulsion cross-linking method using a 2 Results: The optimised FCZ-CMs (F9) exhibited a PS (31.81 ± 1.14 μm), EE (84.12% ± 2.15%), DR (58.46% ± 1.89% at 60 min), and ORT (51.22% ± 2.11% at 30 min), demonstrating excellent suitability for localized oesophageal delivery. FTIR confirmed drug-polymer compatibility, SEM revealed spherical microspheres with a crenated surface morphology favourable for mucoadhesion, while DSC and XRD demonstrated reduced crystallinity of FCZ within the chitosan matrix. The ODTs loaded with F9 displayed high DC (99.14% ± 0.58%), short WT (19.62 ± 0.51s), and DT (23.83 ± 0.86s). The dissolution profile of ODTs remained comparable to that of F9 ( Conclusion: The optimised ODTs successfully translated the performance of FCZ-CMs into a patient-friendly, oesophageal-targeted drug delivery system without compromising their controlled-release or mucoadhesive characteristics. The use of a simple, reproducible, and scalable direct compression process, together with preservation of microsphere functionality following tablet compression, highlights the translational potential of this platform for localized treatment of oesophageal candidiasis and deserves further clinical investigation.
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