ArticleNutrition research and practice2026
Targeting vascular endothelial growth factor (VEGF)-induced angiogenesis with
Article in Nutrition research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesAngiogenesis is essential for tumor growth, tissue repair, and cell development. MATERIALS/
methodsRLE was prepared, chemically profiled by high-performance liquid chromatography, and used in both
resultsRLE inhibited VEGF-induced proliferation, tube formation, migration, and invasion in HUVECs. RLE treatment also reduced the phosphorylation of VEGFR-2 and downstream signaling molecules, including AKT, ERK, and eNOS. Molecular docking supported the potential interaction between major RLE compounds and VEGFR-2. Additionally, RLE inhibited MMP-2-mediated extracellular matrix remodeling and attenuated VEGF-stimulated microvessel sprouting in the aortic ring assay.
conclusionRLE exerts potent anti-angiogenic effects by modulating the VEGF/VEGFR-2 signaling cascade and inhibiting MMP-2 activity. As a previously underutilized botanical resource, RLE may serve as a promising complementary therapeutic agent for diseases related to angiogenesis.
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