Evidence map›Paper›PMID 42889216›Full record

Observational studyTransplant international : official journal of the European Society for Organ Transplantation2026

The frequency and timing of leukopenia and CMV infections in kidney transplant recipients in Finland - a retrospective observational study.

Ilkka Helanterä, Fernanda Ortiz, Essi Havula, Samuli Tuominen, Markus Hakamäki, Tapio Hellman, Satu Mäkelä, Riku Korhonen

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Transplant international : official journal of the European Society for Organ Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ilkka HelanteräTransplantation and Liver Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Fernanda OrtizHelsinki University Hospital, Abdominal Center, Nephrology, Helsinki, Finland.
Essi HavulaMedaffcon Oy, Espoo, Finland.
Samuli TuominenMedaffcon Oy, Espoo, Finland.
Markus HakamäkiKidney Center, Turku University Hospital and University of Turku, Turku, Finland.
Tapio HellmanKidney Center, Turku University Hospital and University of Turku, Turku, Finland.
Satu MäkeläDepartment of Internal Medicine, Tampere University Hospital, Tampere, Finland.
Riku KorhonenMSD Finland, Espoo, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This retrospective observational study investigated the frequency of post-transplant leukopenia and neutropenia (PTLN) and its association with cytomegalovirus (CMV) infections, clinical outcomes, and healthcare resource utilization (HCRU) in kidney transplant recipients (KTRs) in Finland. Clinical and HCRU data were collected from electronic medical records and national registries for the years 2013-2022. Clinical outcomes were assessed during the first 18 months, and cost-related outcomes were evaluated up to 4 years post-transplant. The cohort included 966 KTRs, with the following donor/recipient CMV serostatus distribution: R+ 706 (73.1%), D+/R─ 200 (20.7%), and D─/R─ 60 (6.2%). At 12 months, PTLN occurred in 224 (31.7%) R+, 103 (51.5%) D+/R─, and 6 (10.0%) D─/R─ recipients (p < 0.001). Valganciclovir prophylaxis was started in 28.0% of R+ and 95.0% of D+/R─ patients. CMV DNAemia occurred in 357 (50.6%) R+ and 106 (53.0%) D+/R─ recipients, with median time to CMV DNAemia of 66 days (IQI: 48-110) in R+ and 239 days (IQI: 175-323) in D+/R─ recipients (p < 0.001). PTLN and D+/R─ serostatus were associated with higher HCRU and increased healthcare costs. In conclusion, PTLN was more common in CMV D+/R─ KTRs and both D+/R─ serostatus and PTLN were linked to greater healthcare utilization and cost burden.

Indexed as

Cytomegalovirus InfectionsKidney TransplantationLeukopeniaAdultAntiviral AgentsFemaleFinlandHumansMaleMiddle AgedNeutropeniaRetrospective StudiesTime FactorsValganciclovirAntiviral AgentsValganciclovirCMVkidney transplantationleukopenianeutropeniavalganciclovir

Identifiers

PMID42889216
PMCPMC13668761

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.