ArticleFrontiers in cell and developmental biology2026
Mechanistic study on components of
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Abnormal mechanical load is a critical risk factor for intervertebral disc degeneration (IVDD), and nucleus pulposus (NP) cell senescence is a core pathogenic mechanism in IVDD. Piezo1 is a mechanosensitive ion channel, whereas the NF-κB pathway promotes cellular senescence. The classical formula Duhuo Jisheng decoction has shown potential benefits in IVDD-related conditions, and its core herbal pair Objective: This study aimed to identify the optimal concentration ratio of the Methods: An Results: Compression effectively induced NP cell senescence and activated Piezo1 expression and NF-κB signaling. The CBCM concentration ratio that optimally suppressed senescence markers was quercetin at 50 μM, osthole at 6.25 μM, and columbianadin at 12.5 μM. Mechanistically, the optimized CBCM inhibited Piezo1 expression, NF-κB activation, and p65 nuclear translocation. Both p65 knockdown and Piezo1 inhibition mimicked CBCM's anti-senescent effects, whereas p65 overexpression or Piezo1 agonism reversed these protective effects. These Conclusion: These findings suggest that the optimal
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