ArticleFrontiers in medicine2026
Prognostic value of T lymphocyte CD40L expression levels in patients with sepsis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to analyze the expression characteristics of CD40L on peripheral blood T lymphocytes in patients with sepsis and explore its value in assessing disease severity and prognosis. Methods: This prospective study collected blood samples and clinical data from adult sepsis patients admitted to the Department of Critical Care Medicine at the First Affiliated Hospital of Soochow University between March 2023 and March 2024, with the primary endpoint being 28-day mortality. Multivariate Cox regression analysis was performed to evaluate the association between T lymphocyte CD40L expression and 28-day mortality. Additionally, machine learning algorithms were applied to determine the importance of CD40L-related features, and latent class mixed model analysis was conducted to identify different expression trajectories. Results: A total of 112 sepsis patients were included, with a 28-day mortality rate of 20.5%. CD40L expression levels on peripheral blood CD4 Conclusion: Peripheral blood T lymphocyte CD40L was identified as an independent predictor of 28-day mortality in sepsis patients. Identifying distinct expression trajectories of CD40L in peripheral blood T lymphocytes can effectively assist in predicting short-term prognosis in patients with sepsis.
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