ArticleFrontiers in immunology2026
Development of siRNAs targeting interferon beta as a novel therapeutic approach for adult and juvenile dermatomyositis.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: A key feature of the autoimmune conditions adult and juvenile dermatomyositis (DM/JDM) is the correlation of interferon (IFN) beta induction with disease initiation and activity. Our aim was to establish a short interfering RNA (siRNA) approach to knockdown Methods: A library of 74 siRNAs targeting Results: Initial screening of 27 siRNAs identified two lead siRNAs with significant knockdown of both IFN beta transcript and secreted protein in all cell lines, with one lead siRNA demonstrating a more favourable cytotoxicity profile. RNA sequencing and pathway analysis revealed that both lead siRNAs were able to reduce the induction of disease-associated immune and autoimmune pathways in dermal fibroblasts and JDM myotubes. An additional 47 siRNAs across the Conclusions: Overall, comprehensive
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