SynthesisFrontiers in nutrition2026
Dietary intake and circulating levels of vitamins, antioxidants, and fatty acids in relation to coronary heart disease risk: a systematic review and dose-response meta-analysis.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
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Abstract
Background: Associations between vitamin, antioxidant, and fatty acid exposure and coronary heart disease (CHD) risk remain uncertain, and dose-response relationships are poorly defined. This study aimed to evaluate the overall and dose-response associations between dietary and circulating vitamin, antioxidant, and fatty acid levels and CHD risk from observational evidence. Methods: PubMed, Web of Science, Embase, and the Cochrane Library were searched for studies published up to February 2, 2026 (PROSPERO: CRD420261380823). Eligible observational studies (case-control, cohort, cross-sectional) reporting associations between vitamin, antioxidant, or fatty acid levels and CHD risk were included. A total of 27 studies were analyzed. Categorical (highest vs. lowest) and dose-response analyses were performed, estimating pooled odds ratios (ORs), relative risks (RRs), and hazard ratios (HRs). Results: Twenty-seven observational studies were included. In categorical analyses, higher circulating 25(OH)D (pooled HR = 0.79, 95% CI = 0.74-0.85; Conclusion: In observational studies, selected dietary and circulating vitamin, antioxidant, and fatty acid exposures were associated with CHD risk. These associations do not establish causality or justify specific supplementation recommendations, and findings based on sparse data require confirmation in additional prospective studies.
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