ArticleFrontiers in cell and developmental biology2026
Dynamic phosphorylation of DGCR8 regulates embryonic stem cell differentiation and microprocessor function.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The Microprocessor complex, minimally composed of DROSHA and DGCR8, is ubiquitously required for microRNA biogenesis. It also regulates the balance between pluripotency and differentiation through mRNA alternative splicing and mRNA cleavage. However, how these various activities are regulated remains incompletely understood. Both DROSHA and DGCR8 are phosphoproteins, and phosphorylation has been reported to influence their molecular functions. In this study, we identified residues in DGCR8 by mass spectrometry that were differentially phosphorylated in mouse embryonic stem cells (mESCs) before and after differentiation into neuronal cells. This included S95 that exhibited greater phosphorylation in undifferentiated cells, and S238 that exhibited greater phosphorylation in differentiated cells. By means of CRISPR/Cas9-mediated genome editing of the endogenous
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