Evidence map›Paper›PMID 42889150›Full record

ArticleFrontiers in microbiology2026

4-Hydroxycoumarin inhibits biofilm formation and enhances antibiotic efficacy against

Hongxing Zhang, Jing Xu, Yaxin Zhou, Zhijin Zhang, Zixuan Shang, Bing Li, Yubin Bai, Jiyu Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hongxing Zhang *Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, New Veterinary Drugs Engineering Research Center of Gansu Province, Key Laboratory of New Veterinary Drugs Engineering of CAAS, Laboratory Animal Science Data Center of Gansu Province, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, Gansu, China.
Jing Xu *Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, New Veterinary Drugs Engineering Research Center of Gansu Province, Key Laboratory of New Veterinary Drugs Engineering of CAAS, Laboratory Animal Science Data Center of Gansu Province, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, Gansu, China.
Yaxin ZhouKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, New Veterinary Drugs Engineering Research Center of Gansu Province, Key Laboratory of New Veterinary Drugs Engineering of CAAS, Laboratory Animal Science Data Center of Gansu Province, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, Gansu, China.
Zhijin ZhangKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, New Veterinary Drugs Engineering Research Center of Gansu Province, Key Laboratory of New Veterinary Drugs Engineering of CAAS, Laboratory Animal Science Data Center of Gansu Province, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, Gansu, China.
Zixuan ShangKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, New Veterinary Drugs Engineering Research Center of Gansu Province, Key Laboratory of New Veterinary Drugs Engineering of CAAS, Laboratory Animal Science Data Center of Gansu Province, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, Gansu, China.
Bing LiKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, New Veterinary Drugs Engineering Research Center of Gansu Province, Key Laboratory of New Veterinary Drugs Engineering of CAAS, Laboratory Animal Science Data Center of Gansu Province, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, Gansu, China.
Yubin BaiKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, New Veterinary Drugs Engineering Research Center of Gansu Province, Key Laboratory of New Veterinary Drugs Engineering of CAAS, Laboratory Animal Science Data Center of Gansu Province, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, Gansu, China.
Jiyu ZhangKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, New Veterinary Drugs Engineering Research Center of Gansu Province, Key Laboratory of New Veterinary Drugs Engineering of CAAS, Laboratory Animal Science Data Center of Gansu Province, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Conventional bactericidal antibiotics often fail to eradicate Escherichia coli O157:H7 ( Methods: The effects of 4-HC on biofilm formation, extracellular polymeric substance (EPS) biosynthesis, and flagella-mediated motility were assessed in vitro. Antibiotic potentiation was evaluated through combination assays across multiple antibiotic classes. In vivo efficacy was tested in a murine systemic infection model, with qualitative histological observation used to evaluate splenic, hepatic, and ileal tissue damage. Results: 4-HC disrupted biofilm formation by suppressing EPS biosynthesis and flagella-mediated motility, thereby destabilizing biofilm architecture and impairing bacterial dissemination. 4-HC acted as a broad-range potentiator for most antibiotics tested, with the most pronounced effect observed in combination with fosfomycin sodium. This combination reduced systemic bacterial burden and restored intestinal barrier function Conclusion: 4-HC disrupts biofilm formation and enhances antibiotic efficacy against

Indexed as

4-hydroxycoumarinbiofilmEscherichia coli O157:H7LuxSQS

Identifiers

PMID42889150
PMCPMC13669101

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.