ArticleFrontiers in immunology2026
Lycium barbarum polysaccharides modulate SOCS-1 gene methylation and promote the maturation and migration of human monocyte-derived dendritic cells
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the effects of Methods: Human monocyte-derived DCs were generated using recombinant human GM-CSF and interleukin-4 (IL-4) and treated with various concentrations of LBPs (50, 100, and 200 mg/L). SOCS-1 methylation and relative gene expression were analyzed by methylation-specific quantitative PCR (qMSP) and quantitative real-time PCR, respectively. DC surface markers were assessed by flow cytometry. Cytokine (IL-12 and IL-10) secretion was measured by enzyme-linked immunosorbent assay (ELISA). JAK2, STAT3 and STAT5 phosphorylation were assessed by Western Blot Analysis. The ability of LBPs-treated DCs to stimulate lymphocyte proliferation was evaluated in a mixed lymphocyte reaction (MLR). DC migration was tested using a Transwell assay toward MIP-3β, and CCR7 expression was quantified by real-time PCR. Results: LBPs treatment upregulated SOCS-1 gene methylation and increased the expression of maturation markers (CD80, CD83, HLA-DR) and IL-12 production in a dose-dependent manner. Conversely, SOCS-1 expression and IL-10 secretion were downregulated. Furthermore, LBPs-treated DCs enhanced allogeneic lymphocyte proliferation. A significant increase in DC migration toward MIP-3β and CCR7 expression was observed in the 200 mg/L LBPs group compared to the control. Conclusion: These findings indicate that LBPs are associated with increased SOCS-1 methylation and enhanced maturation and migratory capacity of human monocyte-derived DCs
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