ArticleFrontiers in endocrinology2026
Association between the cholesterol-high-density lipoprotein-glucose (CHG) index and albuminuria risk in diabetic patients.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The Cholesterol-High-Density Lipoprotein-Glucose (CHG) index is a novel composite metabolic biomarker. We aimed to evaluate the relationship between the CHG index and albuminuria prevalence in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 1842 T2DM patients at Jinjiang Municipal Hospital were enrolled in this cross-sectional study. Albuminuria was defined as a urinary albumin-to-creatinine ratio (UACR) > 30 mg/g. Multivariable logistic regression, restricted cubic spline modeling, subgroup analyses, and receiver operating characteristic (ROC) curve analysis were performed to evaluate the independent association. Results: Patients with albuminuria (n=324) had higher CHG index values. After full adjustment, an elevated CHG index was significantly associated with higher odds of albuminuria ( Conclusions: The CHG index was nonlinearly associated with albuminuria prevalence in patients with T2DM; however, its cross-sectional design precludes causal inference.
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