Evidence map›Paper›PMID 42889101›Full record

ArticleFrontiers in nutrition2026

Food-based formula modulates gut microbial homeostasis and inflammatory responses following LPS challenge in mice.

Xiaolan Ying, Jing Li, Yue Tang, Guoliang Lu, Li Hong, Zhiyan Zhan

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaolan YingDepartment of Clinical Nutrition, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing LiDepartment of Clinical Nutrition, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yue TangDepartment of Clinical Nutrition, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Guoliang LuDepartment of Clinical Nutrition, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li HongDepartment of Clinical Nutrition, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhiyan ZhanDepartment of Clinical Nutrition, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Oral nutritional supplements (ONSs) are widely used to support patients with malnutrition or chronic diseases. However, their potential effects on inflammatory recovery and gut microbial composition remain insufficiently understood. This study evaluated a novel whole-food-based formula (FBF) composed of natural food-derived ingredients and investigated its effects on inflammation recovery and gut microbiota in a murine model of lipopolysaccharide (LPS)-induced low-grade inflammation. Methods: 21 male C57BL/6J mice were randomly assigned to a healthy control (HC) group, a milk-based formula (MBF) group, or a food-based formula (FBF) group. Mild systemic inflammation was induced by intraperitoneal injection of LPS (3 mg/kg). After LPS administration, mice received dietary intervention for 10 days. Serum inflammatory cytokines, colonic histopathology, and gut microbiota profiles were evaluated by ELISA, hematoxylin-eosin staining, and 16S rRNA gene sequencing, respectively. Results: Serum IL-6 concentrations were elevated in the MBF group compared with healthy controls ( Conclusion: A whole-food-based nutritional formula was associated with lower serum IL-6 levels and distinct gut microbial compositional profiles compared with a milk-based formula following LPS-induced inflammation. These findings suggest FBF may influence inflammatory recovery and gut microbial composition; however, further functional and mechanistic studies are required to clarify its biological effects.

Indexed as

dietary interventionfood-based formulagut microbiotainflammationintestinal barrieroral nutritional supplement

Identifiers

PMID42889101
PMCPMC13668561

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.