Evidence map›Paper›PMID 42889093›Full record

ArticleFrontiers in medicine2026

Factors associated with high-grade cervical dysplasia in colposcopy patients: the primary role of isolated HPV 16 positivity.

Alihan Tigli, Yakup Baykus, Rulin Deniz, Oguzhan Karakoc, Guzide Ece Akinci, Nazli Sener, Yasemin Ercan Degirmenci, Erdem Gurkan, Engin Korkmazer, Seyda Yavuzkir and 4 more

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Alihan TigliDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Bandırma Onyedi Eylül University, Bandırma, Türkiye.
Yakup BaykusDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Bandırma Onyedi Eylül University, Bandırma, Türkiye.
Rulin DenizDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Bandırma Onyedi Eylül University, Bandırma, Türkiye.
Oguzhan KarakocGynecology and Obstetrics Clinic, Bandırma Training and Research Hospital, Bandırma, Türkiye.
Guzide Ece AkinciGynecology and Obstetrics Clinic, Şehit Prof. Dr. İlhan Varank Sancaktepe Training and Research Hospital, Istanbul, Türkiye.
Nazli SenerDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Bandırma Onyedi Eylül University, Bandırma, Türkiye.
Yasemin Ercan DegirmenciDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Bandırma Onyedi Eylül University, Bandırma, Türkiye.
Erdem GurkanGynecology and Obstetrics Clinic, Bandırma Training and Research Hospital, Bandırma, Türkiye.
Engin KorkmazerObstetrics and Gynecology Private Practice, Bursa, Türkiye.
Seyda YavuzkirDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Fırat University, Elazığ, Türkiye.
Ahmet YilmazDepartment of Medical Biochemistry, Faculty of Medicine, Fırat University, Elazığ, Türkiye.
Berrak Yildirim AksakalDepartment of Medical Education, Faculty of Medicine, Fırat University, Elazığ, Türkiye.
Sermin KilicDepartment of Obstetrics and Gynecology, Elazığ Fethi Sekin City Hospital, Elazığ, Türkiye.
Suleyman AydinDepartment of Medical Biochemistry, Faculty of Medicine, Fırat University, Elazığ, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cervical cancer is the fourth most common cancer and a leading cause of cancer-related fatalities among women globally. Implementing personalized follow-up strategies is crucial for effective prevention of cervical cancer. The present investigation sought to delineate risk factors associated with the development of cervical intraepithelial neoplasia (CIN) in patients undergoing colposcopy through an analysis of colposcopy indications and histopathological outcomes. Methods: This retrospective study included 394 patients aged 30-65 years who underwent colposcopy at Bandırma Onyedi Eylül University Faculty of Medicine Hospital between June 2022 and January 2025 due to high-risk Human Papillomavirus (HR-HPV) positivity, abnormal cervical cytology, or persistent clinical suspicion. The indications for colposcopy, histopathology results, and demographic characteristics such as age and smoking status were analyzed. Results: The mean age of the patients was 44.5 ± 10.9 years. The primary indication for colposcopy was observed to be isolated HPV 16 positivity, which accounted for 28% ( Conclusions: Isolated HPV 16 positivity was independently associated with an approximately 2.4-fold increase in the odds of CIN II-III after adjustment for age and smoking status. This finding reinforces the central role of HPV 16 in identifying women at higher risk for high-grade cervical dysplasia and supports its prioritization in risk-based colposcopy and follow-up strategies.

Indexed as

agecervical dysplasiacervical intraepithelial neoplasiaCINcolposcopyHPV

Identifiers

PMID42889093
PMCPMC13668805

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