Evidence map›Paper›PMID 42888891›Full record

ArticleUnited European gastroenterology journal2026

Symptom Profiles Compatible With Disorders of Gut-Brain Interaction in Individuals With Coeliac Disease on a Long-Term Gluten-Free Diet.

Tom van Gils, Hans Törnblom, Floris van Overveld, Olafur S Palsson, Ami D Sperber, Shrikant I Bangdiwala, Inês A Trindade, Marc A Benninga, Gerd Bouma, Magnus Simrén

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Article in United European gastroenterology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Tom van GilsDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0009-0006-2103-9491
Hans TörnblomDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0003-2117-9874
Floris van OverveldDutch Coeliac Society, Naarden, the Netherlands.ORCID https://orcid.org/0009-0009-9715-7306
Olafur S PalssonUniversity of North Carolina/Chapel Hill, Chapel Hill, North Carolina, USA.
Ami D SperberFaculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.ORCID https://orcid.org/0000-0002-7634-3689
Shrikant I BangdiwalaDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-3111-0689
Inês A TrindadeEMBRACE Lab, Center for Health and Medical Psychology, Örebro University, Örebro, Sweden.ORCID https://orcid.org/0000-0003-1208-2077
Marc A BenningaDepartment of Paediatric Gastroenterology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-9406-9188
Gerd BoumaAmsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0002-0084-5092
Magnus SimrénDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-1155-1313

Funding

AllerganDutch coeliac societyIronwoodShireTakeda
6 · The paper itself

Abstract

backgroundPersistent gastrointestinal (GI) symptoms are frequently reported in patients with coeliac disease (CD). Knowledge about the role of disorders of gut-brain interaction (DGBI) as the cause of these persistent symptoms remains limited.

objectiveTo assess the prevalence and factors associated with DGBI-compatible symptom profiles in individuals with CD on a long-term gluten-free diet (GFD).

methodsAdult members of the Dutch Coeliac Society completed an online survey, including the Rome IV diagnostic questionnaire and validated questionnaires assessing psychological distress, non-GI somatic symptom severity, and health-related quality of life (QOL). Only individuals with CD adhering to a GFD ≥ 1 year were included. A population-based Dutch cohort served as the reference group.

resultsAmong 1001 participants with CD (79.3% female; median age 50 years), 64.8% met the criteria for ≥ 1 DGBI-compatible symptom profile compared with 31.3% in the reference group (for confounders adjusted odds ratio (AOR) 3.2 (95% CI 2.6-3.8)). Irritable bowel syndrome showed the strongest association with CD (AOR 4.5 (95% CI 3.3-6.2)). Having DGBI-compatible symptom profiles was, like the reference group, associated with higher levels of psychological distress and non-GI somatic symptom severity and lower health-related QOL.

conclusionsRome IV DGBI-compatible symptom profiles are highly prevalent in individuals with CD on a long-term GFD and are associated with impaired QOL. While ongoing gluten exposure and other comorbidities could not be excluded, these findings support the consideration of DGBI in the evaluation and treatment of persistent symptoms in patients with CD.

Indexed as

Brain-Gut AxisCeliac DiseaseDiet, Gluten-FreeIrritable Bowel SyndromeAdultAgedFemaleHumansMaleMiddle AgedNetherlandsPrevalenceQuality of LifeSeverity of Illness IndexSurveys and QuestionnairesSymptom Burdencoeliac diseasedisorders of gut‐brain interactionepidemiologyirritable bowel syndromequality of life

Identifiers

PMID42888891
PMCPMC13675726

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.