ArticleBrain pathology (Zurich, Switzerland)2026
Effects of postmortem interval on myelin integrity in rhesus macaque brain tissue.
Article in Brain pathology (Zurich, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
When conducting microscopy of human brain sections, the postmortem interval (PMI) introduces myelin-related artifacts that can confound neuropathological interpretation, yet the extent and detectability of these changes remain poorly characterized. This study examined the impact of controlled PMI on myelin integrity in rhesus macaque brain tissue using advanced optical imaging approaches. Brains from five aged rhesus macaques (20.5-28.5 years) were maintained at 4°C and analyzed at 0, 24, and 72 h postmortem. Myelin integrity in white and gray matter was assessed using quantitative birefringence microscopy to measure relative retardance and polarization-sensitive optical coherence tomography to quantify scattering coefficients, retardance, and volumetric features. Increasing PMI was associated with progressive myelin degradation, reflected by significant reductions in relative optical retardance in white matter (p < 0.01) and gray matter (p < 0.001), alongside increased scattering coefficients in both regions (p < 0.001). Morphological analyses revealed a marked increase in myelin defects per mm
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