Evidence map›Paper›PMID 42888767›Full record

ArticlePhysical review. E2026

Discovering interpretable low-dimensional dynamics using maximum entropy.

Michael C Chung, Tarran Mohan, Purushottam D Dixit, Juan Guan

Abstract read
In one paragraph

Article in Physical review. E, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael C ChungUniversity of Texas at Austin, College of Pharmacy, Division of Chemical Biology and Medicinal Chemistry, Austin, Texas 78712, USA.
Tarran MohanUniversity of Texas at Austin, College of Pharmacy, Division of Chemical Biology and Medicinal Chemistry, Austin, Texas 78712, USA.
Purushottam D DixitYale University, Department of Biomedical Engineering, New Haven, Connecticut 06511, USA.
Juan GuanUniversity of Texas at Austin, College of Pharmacy, Division of Chemical Biology and Medicinal Chemistry, Austin, Texas 78712, USA.

Funding

Mechanisms of Assembly and Functional Regulation in Non-canonical Biomolecular CondensatesR35GM146877 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Juan Guan · 2022 to 2026
$2.0M
MANET: Maximum Entropy Neural Networks for Mechanistic Modeling of Single Cell BehaviorR35GM142547 · NIGMS · YALE UNIVERSITY · PI DIXIT, PURUSHOTTAM · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM142547NIGMS NIH HHS R35 GM146877
6 · The paper itself

Abstract

Models (i.e., governing equations) are fundamental to science and engineering. Advances in data acquisition now make it possible to extract interpretable, low-dimensional descriptions from high-dimensional observations. However, existing approaches sacrifice either interpretability for reconstruction accuracy or infer symbolic dynamics without relating latent coordinates to physically meaningful observables. Here we present Edwin (maximum entropy-driven compression with interpretable nonlinear model discovery), a unified framework that simultaneously performs dimensionality reduction using the dynamic maximum entropy (DME) principle and discovers sparse symbolic models governing latent dynamics, as well as the coupling between learned features and external metadata. We validate Edwin on diverse simulated systems, including stochastic diffusion, the Ornstein-Uhlenbeck process, self-assembling particles, and neural population firing rates, as well as on a noisy experimental time series of aggregating RNA-liposome complexes. Across all systems, Edwin recovers low-dimensional symbolic models that are physically interpretable and generalize to unseen conditions. Together, these results establish Edwin as a principled framework for inferring interpretable, low-dimensional dynamics from high-dimensional nonnegative data.

Identifiers

PMID42888767
PMCPMC13679066

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.