ArticleMedicine2026
Gut microbiota, sleep and coronary artery disease: A Mendelian randomization study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inadequate and poor-quality sleep is increasingly recognized as a risk factor for coronary artery disease (CAD). Gut microbiota may play a role in sleep regulation. However, the associations between gut microbiota, sleep, and CAD risk, and the causal nature of these associations, remain unclear. We performed a 2-step Mendelian randomization analysis using summary-level data to assess the association between gut microbiota and CAD and the potential mediating roles of sleep-related traits (i.e., chronotype, insomnia, sleep duration, short sleep, and long sleep) herein. The inverse-variance weighted method served as the primary analysis, with several other complementary methods as sensitivity analyses. Our findings revealed that 2 gut microbial taxa were negatively associated with genetically predicted CAD risk, while 4 taxa, including species Veillonella unclassified (odds ratio: 1.054, 95% confidence interval: 1.010-1.101), showed positive associations. Regarding sleep-related traits, we found that insomnia (odds ratio: 1.553, 95% confidence interval: 1.081-2.230) and short sleep duration causally increased CAD risk, whereas longer sleep duration causally reduced CAD risk. The mediation Mendelian randomization analysis demonstrated that insomnia partially mediated the causal, predisposing effect of species Veillonella unclassified on increased CAD risk, with a proportion mediated of 5.7%. This study provides evidence for a causal relationship between specific gut microbial taxa and CAD risk, as well as the mediating role of insomnia in this relationship. These findings offer novel insights into potential strategies for CAD prevention through modulation of the gut microbiome and improvement of sleep quality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.