ArticleMedicine2026
Comparative efficacy of two novel bioceramic root canal sealers in the treatment of chronic apical periodontitis.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Chronic apical periodontitis (CAP) is a persistent periradicular inflammatory condition driven by intraradicular infection and remains a common indication for primary nonsurgical root canal therapy. This retrospective cohort study compared 2 calcium silicate-based bioceramic root canal sealers (C-Root SP vs iRoot SP) used during obturation in adults treated for CAP between January 2022 and December 2024. CAP was confirmed by compatible clinical findings and radiographic evidence of periapical radiolucency; cone-beam computed tomography (CBCT) was obtained when clinically indicated. The primary endpoint was a strict composite treatment success endpoint requiring both clinical resolution and radiographic healing at final follow-up. Secondary outcomes included pain severity measured by the visual analog scale (VAS) and treatment-related events. Among 227 eligible patients, 209 were included in the final analysis (C-Root SP, n = 101; iRoot SP, n = 108). Treatment success was higher with C-Root SP than with iRoot SP (86.1% vs 74.1%; χ2 = 4.73, P = .030), and radiographic healing was also more frequent (88.1% vs 76.9%; χ2 = 4.55, P = .033), whereas clinical resolution did not differ statistically (91.1% vs 83.3%; P = .095). After adjustment for age, sex, baseline lesion diameter, tooth location, diabetes mellitus, and baseline sinus tract, C-Root SP was associated with higher odds of treatment success (adjusted odds ratio [aOR] = 2.25, 95% confidence interval [CI]: 1.09-4.65; P = .028) and radiographic healing (aOR = 2.23, 95% CI: 1.04-4.79; P = .040), while the adjusted association with clinical resolution was not statistically significant (aOR = 2.12, 95% CI: 0.89-5.09; P = .091). VAS trajectories were similar overall, with a modest between-group difference at 1 month. Postoperative pain, acute exacerbations, sealer extrusion, and further endodontic interventions were infrequent and comparable between groups. In exploratory analysis, sealer extrusion was associated with treatment failure (OR = 4.91, P = .002). These observational findings indicate associations rather than causal treatment effects and require prospective confirmation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.