Evidence map›Paper›PMID 42888424›Full record

ArticleJournal of translational medicine2026

PAFAH1B1 stabilization, through PUM2-mediated competitive binding with miRNAs on its' 3'-UTR, takes active actions on ferroptosis to overcome the radioresistance to

Yiliang Bi, Wei Shen, Cuiyun Ma, Airong Tang, Kaiyu Jian, Lin Jiang, Yan Liu, Min Min

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Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yiliang BiSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, No. 28 Fuxing Road, Beijing, 100071, China.
Wei ShenSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, No. 28 Fuxing Road, Beijing, 100071, China.
Cuiyun MaSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, No. 28 Fuxing Road, Beijing, 100071, China.
Airong TangSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, No. 28 Fuxing Road, Beijing, 100071, China.
Kaiyu JianSenior Department of General Surgery, The First Medical Center of PLA General Hospital, Beijing, 100071, China.
Lin JiangSenior Department of General Surgery, The First Medical Center of PLA General Hospital, Beijing, 100071, China.
Yan LiuSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, No. 28 Fuxing Road, Beijing, 100071, China. 13911798288@163.com.
Min MinSenior Department of Gastroenterology, The First Medical Center of PLA General Hospital, No. 28 Fuxing Road, Beijing, 100071, China. minmin823@sina.com.ORCID http://orcid.org/0009-0003-4191-6779

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPancreatic cancer is one of the most fatal malignancies with the lowest 5-year survival worldwide. Radioresistance remains the major challenge for pancreatic cancer treatment. The aim of this study is to unravel the mechanism underlying PAFAH1B1-regulated radiosensitivity in pancreatic ductal adenocarcinoma (PDAC).

methodsImmunohistochemistry (IHC), western blot or qRT-PCR were employed to detect the expression of PAFAH1B1, PUM2 and other molecules. Two radiation-resistant (RR) PDAC cell lines and a xenograft mouse model were established. CCK-8, colony formation assays and flow cytometry analysis were used to assess cell proliferation and apoptosis in PDAC cells, respectively. Ferroptosis was evaluated using commercial kits and BODIPY 581/591 C11 staining. The association between PUM2 and PAFAH1B1 3'UTR, as well as between miR-421/miR-301a-3p and PAFAH1B1 3'UTR, were detected by luciferase and RNA immunoprecipitation (RIP) assays.

resultsPAFAH1B1 was downregulated in PDAC, and it was associated with unfavorable prognosis and radiotherapy response of PDAC patients. PAFAH1B1 overexpression enhanced the radiosensitivity to

conclusionPUM2/PAFAH1B1 axis decreased the radioresistance to

Indexed as

3' Untranslated RegionsCarcinoma, Pancreatic DuctalFerroptosisMicroRNAsMicrotubule-Associated ProteinsPancreatic NeoplasmsRadiation ToleranceRNA-Binding ProteinsAnimalsBase SequenceCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMale3' Untranslated RegionsMicroRNAsMicrotubule-Associated ProteinsPUM2 protein, humanRNA-Binding ProteinsFerroptosisPAFAH1B1PDACPUM2Radiosensitivity

Identifiers

PMID42888424

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.