Observational studyBMC pediatrics2026
Association between vancomycin trough concentration monitoring and gestational age in neonates: a single-center, retrospective observational study.
Observational study in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe vancomycin dosing regimen for neonates is primarily determined by gestational age (GA) and postnatal age(PNA). Nonetheless, initial trough concentrations frequently fall below therapeutic levels in neonates administered vancomycin. This study seeks to examine the relationship between vancomycin trough concentrations and gestational age in neonates, thereby offering a reference for individualized vancomycin dosing tailored to neonates of varying gestational ages.
methodsA retrospective observational study was undertaken to collect clinical data on neonates treated with vancomycin and subjected to trough concentration monitoring in the Neonatal Intensive Care Unit (NICU) at Northwest Women's and Children's Hospital over the preceding six years.
resultsUtilizing a two-piecewise linear regression model, the P-value for the log-likelihood ratio was 0.007, indicating statistical significance, and an inflection point was identified at 34.6 weeks(approximately 242 days). For gestational ages less than 34.6 weeks, a positive correlation was observed between GA and the initial vancomycin trough concentration (TCV) (β = 0.08, 95% CI: 0.01, 0.14, p = 0.021). Conversely, for gestational ages exceeding 34.6 weeks, a negative trend of borderline significance (β = -0.10, 95% CI: -0.20 to 0.00, P = 0.059).
conclusionVancomycin trough concentrations in neonates exhibit a significant correlation with GA. This retrospective study, conducted at a single center, revealed a non-linear relationship between gestational age and initial vancomycin trough concentrations in neonates, identifying an inflection point at approximately 34.6 weeks. The results indicate that existing gestational age-based dosing protocols may inadequately account for pharmacokinetic transitions, underscoring the necessity for prospective studies to validate therapeutic drug monitoring protocols stratified by gestational age.
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