Evidence map›Paper›PMID 42888364›Full record

ArticleJapanese journal of radiology2026

Palliative radiotherapy for gastric cancer-related bleeding: a systematic review and meta-analysis of bleeding response and dose-response relationships.

Ruka Iguchi, Nobuki Imano, Tetsuo Saito, Shota Miyoshi, Takaaki Matsuura, Daisuke Kawahara, Ikuno Nishibuchi, May Abdel-Wahab, Yuji Murakami

Abstract read
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In one paragraph

Article in Japanese journal of radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruka IguchiDepartment of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Nobuki ImanoDepartment of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. imano@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0002-7668-1506
Tetsuo SaitoDivision of Integrative Medical Oncology, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
Shota MiyoshiDepartment of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Takaaki MatsuuraDepartment of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Daisuke KawaharaDepartment of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Ikuno NishibuchiDepartment of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
May Abdel-WahabDivision of Human Health, International Atomic Energy Agency, Vienna, Austria.
Yuji MurakamiDepartment of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.

Funding

Japan Society for the Promotion of Science 26K10610
6 · The paper itself

Abstract

purposePalliative radiotherapy is commonly used to control bleeding in advanced gastric cancer; however, the optimal dose-fractionation regimen as well as the dose-response relationship remain unclear. We aimed to evaluate the effectiveness of radiotherapy for gastric cancer-related bleeding and its association with dose fractionation. MATERIALS AND

methodsWe systematically searched PubMed, Scopus, Web of Science, Cochrane Library, and Ichushi-Web for studies published between January 2000 and August 2026 on palliative radiotherapy for gastric cancer-related bleeding. The primary endpoint was bleeding response rate. A random-effects meta-analysis was performed to estimate the pooled response rates. Meta-regression and subgroup analyses were conducted to explore dose-response relationships. Meta-regression was performed using study-level median biologically effective dose (BED) values.

resultsA total of 31 studies were included. The pooled bleeding response rate was 75.9% (95% confidence interval, 69.7-81.2), with significant heterogeneity (I

conclusionsPalliative radiotherapy is an effective and well-tolerated treatment for gastric cancer-related bleeding. Although study-level meta-regression identified a statistical association between higher BED and hemostatic response, this may largely reflect selection bias and methodological limitations rather than a true dose-response relationship. Given the poor prognosis of this population, shorter dose-fractionation regimens are appropriate for many patients, whereas higher-BED regimens remain reasonable for selected patients.

Indexed as

BleedingDose–responseGastric cancerHemostasisMeta-analysisPalliative radiotherapy

Identifiers

PMID42888364

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.