Evidence map›Paper›PMID 42888346›Full record

ArticleHuman genetics2026

A genome-wide association study of cognitive impairment in a Chinese cohort of 1,040 individuals.

Maggie Haitian Wang, Yexian Zhang, Rui Sun, Fudong Li, Tao Zhang, Xue Gu, Jingzhi Lou, Lirong Cao, Shimin Su, Hong Zheng and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Human genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maggie Haitian Wang *Center for Clinical Research and Biostatistics, JC School of Public Health and Primary Care (JCSPHPC), The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China. maggiew@cuhk.edu.hk.
Yexian Zhang *Beth Bioinformatics Co. Ltd, Hong Kong SAR, China.
Rui Sun *School of Medicine, Warshel Institute for Computational Biology, The Chinese University of Hong Kong (CUHK-SZ), 2001 Longxiang Road, Shenzhen, 518172, China.
Fudong Li *Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, 310051, China.
Tao Zhang *Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, 310051, China.
Xue GuZhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, 310051, China.
Jingzhi LouCenter for Clinical Research and Biostatistics, JC School of Public Health and Primary Care (JCSPHPC), The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China.
Lirong CaoCenter for Clinical Research and Biostatistics, JC School of Public Health and Primary Care (JCSPHPC), The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China.
Shimin SuCenter for Clinical Research and Biostatistics, JC School of Public Health and Primary Care (JCSPHPC), The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China.
Hong ZhengCenter for Clinical Research and Biostatistics, JC School of Public Health and Primary Care (JCSPHPC), The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China.
Caiqi LiuCenter for Clinical Research and Biostatistics, JC School of Public Health and Primary Care (JCSPHPC), The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China.
Marc Ka Chun ChongCenter for Clinical Research and Biostatistics, JC School of Public Health and Primary Care (JCSPHPC), The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China.
William Ka Kei WuDepartment of Anaesthesia and Intensive Care, CUHK, Hong Kong SAR, China.
Jun YuLi Ka Shing Institute of Health Sciences, CUHK, Hong Kong SAR, China.
Benny Chung-Ying ZeeCenter for Clinical Research and Biostatistics, JC School of Public Health and Primary Care (JCSPHPC), The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China.
Junfen LinZhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, 310051, China. jflin@cdc.zj.cn.

Funding

CUHK Direct Grant 2025.084Hong Kong RGC General Research Fund (GRF) 14105925Hong Kong RGC Research Fellowship Scheme RFS2526-4S03National Natural Science Foundation of China 32322088Warshel Institute for Computational Biology funding from Shenzhen City and Longgang District LGKCSDPT2025001Zhejiang Provincial Natural Science Foundation of China LTGY24H260004
6 · The paper itself

Abstract

While genetic heritability plays a major role in the development of cognitive impairment, most genetic risk factors are identified from studies of European populations. We conducted a genome-wide association study (GWAS) on cognitive impairment in the Chinese population by sequencing 1,040 matched case-control individuals from a longitudinal cohort of Zhejiang Province, China. We detected 19 SNPs clustered in 15 genomic loci reaching suggestive significance (P < 1 × 10

Indexed as

Alzheimer DiseaseCognition DisordersCognitive DysfunctionGenome-Wide Association StudyAgedAsian PeopleCadherinsCase-Control StudiesChinaCohort StudiesEast Asian PeopleFemaleGenetic Predisposition to DiseaseHumansMalePolymorphism, Single NucleotideCadherins

Identifiers

PMID42888346

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.