Evidence map›Paper›PMID 42888326›Full record

ReviewBioresources and bioprocessing2026

Microbial cell factories for gamma-linolenic acid biosynthesis: metabolic engineering, downstream processing, and future perspectives.

Jie Qiao, Wei Wang, Peiyao Duan, Zhili Zhang, Rongrong Yang, Haiyang Cui, Xiujuan Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Bioresources and bioprocessing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jie Qiao *State Key Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, China.
Wei Wang *State Key Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, China.
Peiyao Duan *State Key Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, China.
Zhili ZhangState Key Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, China.
Rongrong YangState Key Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, China.
Haiyang CuiSchool of Life Sciences, Nanjing Normal University, Nanjing, 210097, China.
Xiujuan LiState Key Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, China. lixiujuan@njnu.edu.cn.

Funding

Basic Research Program of Jiangsu BK20250141National Natural Science Foundation of China 22478199Qinglan Project of Jiangsu Province of China Qinglan Project of Jiangsu Province of China
6 · The paper itself

Abstract

Gamma-linolenic acid (GLA) is a vital anti-inflammatory polyunsaturated fatty acid, yet its traditional supply from plant seeds such as evening primrose and borage is constrained by low yields and climatic instability. Consequently, microbial cell factories present a sustainable and season-independent alternative for scalable GLA production. This review critically synthesizes recent biotechnological advancements in utilizing oleaginous microorganisms as production platforms. It systematically elucidates the microbial lipid biosynthesis pathways and evaluates strategies to enhance GLA accumulation, with particular emphasis on rational metabolic engineering. Furthermore, emerging technologies for microbial lipid production, alongside the latest progress in industrial-scale applications, are thoroughly examined. Finally, comprehensive insights are provided to guide the optimization of the entire value chain, ranging from upstream strain engineering to downstream processing.

Indexed as

BiosynthesisGamma-linolenic acid (GLA)Machine learningMetabolic engineeringMicrobial lipids

Identifiers

PMID42888326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.