ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
Identification of a novel Microbacterium species and biosynthesis of gold nanoparticles: activation of apoptosis and dysregulation of ABCG transporters in gastric adenocarcinoma cells.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gastric cancer has high morbidity and mortality rates worldwide, often requiring new therapeutic approaches. Biosynthesis of gold nanoparticles (GNPs) offers a promising treatment due to their unique biological properties and biocompatibility. In this study, we synthesized gold nanoparticles using the cultural supernatant of Microbacterium sp. MAH-37 (MM37-S) and evaluated their anti-gastric cancer activity, focusing on apoptosis induction and regulation of the ABCG transporter pathway. The Microbacterium sp. strain MAH-37 was isolated from pumpkin garden soil, and its morphology was characterized by transmission electron microscopy (TEM). The successful biosynthesis of MM37-S-GNP was confirmed by UV-visible spectroscopy, SAED, DLS, FTIR, XRD, EDX, and FE-TEM analyses. Biological evaluations revealed that MM37-S-GNPs exhibited cytotoxicity of approximately 72% at 200 µg/mL against AGS cells and confirmed by colony formation and Live/Dead assay, whereas normal HFE-145 cells was non-toxic. Furthermore, Hoechst 33,258, propidium iodide, and Mito Tracker revealed nuclear condensation and fragmentation, membrane-compromised cells, and mitochondrial disruption, respectively, indicating cell death via apoptosis. H
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