Evidence map›Paper›PMID 42888286›Full record

ArticlePituitary2026

Pro- and anti-inflammatory cytokine dysregulation in the saliva of patients with acromegaly: a cross-sectional study.

Renata Carvalho Campelo, Mila Roselaine Lima de Assunção, Jessilene Ribeiro Rocha, Luís Gustavo Souza Santos, Erika Sales Lopes, Sabrina da Silva Pereira Damianse, Rossana Santiago de Sousa Azulay, Manuel Dos Santos Faria, Gilvan Cortês Nascimento, Vandilson Pinheiro Rodrigues

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Article in Pituitary, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Renata Carvalho CampeloDentistry Graduate Program, Federal University of Maranhão, Avenida dos Portugueses, 1966, Bacanga, São Luís, Maranhão, 65080-805, Brazil.
Mila Roselaine Lima de AssunçãoDentistry Graduate Program, Federal University of Maranhão, Avenida dos Portugueses, 1966, Bacanga, São Luís, Maranhão, 65080-805, Brazil.
Jessilene Ribeiro RochaDentistry Graduate Program, Federal University of Maranhão, Avenida dos Portugueses, 1966, Bacanga, São Luís, Maranhão, 65080-805, Brazil.
Luís Gustavo Souza SantosDentistry Graduate Program, Federal University of Maranhão, Avenida dos Portugueses, 1966, Bacanga, São Luís, Maranhão, 65080-805, Brazil.
Erika Sales LopesResearch Group in Clinical and Molecular Endocrinology and Metabolism, Federal University of Maranhão, São Luís, Brazil.
Sabrina da Silva Pereira DamianseResearch Group in Clinical and Molecular Endocrinology and Metabolism, Federal University of Maranhão, São Luís, Brazil.
Rossana Santiago de Sousa AzulayResearch Group in Clinical and Molecular Endocrinology and Metabolism, Federal University of Maranhão, São Luís, Brazil.
Manuel Dos Santos FariaResearch Group in Clinical and Molecular Endocrinology and Metabolism, Federal University of Maranhão, São Luís, Brazil.
Gilvan Cortês NascimentoResearch Group in Clinical and Molecular Endocrinology and Metabolism, Federal University of Maranhão, São Luís, Brazil.
Vandilson Pinheiro RodriguesDentistry Graduate Program, Federal University of Maranhão, Avenida dos Portugueses, 1966, Bacanga, São Luís, Maranhão, 65080-805, Brazil. vandilson.rodrigues@ufma.br.ORCID http://orcid.org/0000-0002-6785-7864

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 01
6 · The paper itself

Abstract

backgroundThere is evidence to suggest that hormonal dysregulation induced by acromegaly may affect serum cytokine levels. However, to our knowledge, no previous studies have examined the salivary cytokine profile in adults with acromegaly. The aim of this study was to identify the salivary profile of pro- and anti-inflammatory cytokines associated with acromegaly in adults.

methodsA cross-sectional study was conducted with 25 patients with acromegaly and age-, 25 age- and sex-matched controls. Demographic and general health data were collected. Saliva samples were obtained to quantify the concentrations of IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-22, TGF-α, and TNF-α. Statistical analyses included the Mann-Whitney test, Spearman's correlation, and ROC curve analysis.

resultsPatients with acromegaly exhibited significantly higher salivary levels of IL-4, IL-6, IL-10, TGF-α, and TNF-α (p<0.001), as well as IL-17A (p=0.029). No significant differences were observed for isolated IL-1β and IL-22. Comparative analysis showed significantly lower IL-22/IL-4 (p<0.001), IL-1β/IL-10 (p=0.023), and IL-22/IL-10 (p=0.003) ratios in patients with acromegaly compared with controls. Given that IL-1β and IL-22 did not differ significantly between groups, whereas IL-4 and IL-10 were increased in acromegaly, these lower ratios appear to primarily reflect higher levels of the anti-inflammatory cytokines. In multivariate analysis, IL-4, IL-6, IL-17A, IL-22, and TNF-α remained statistically associated with acromegaly.

conclusionThe study findings suggest that patients with acromegaly exhibit a significant imbalance in the levels of pro- and anti-inflammatory cytokines in saliva, with emphasis on IL-4, IL-6, IL-17A, IL-22, and TNF-α.

Indexed as

AcromegalyCytokinesSalivaAdultAgedCross-Sectional StudiesFemaleHumansInterleukin-10Interleukin-17Interleukin-1betaInterleukin-22Interleukin-4Interleukin-6InterleukinsMaleCytokinesInterleukin-10Interleukin-17Interleukin-1betaInterleukin-22Interleukin-4Interleukin-6InterleukinsTumor Necrosis Factor-alphaAcromegalyCytokinesInflammationSaliva

Identifiers

PMID42888286

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.