ArticleRadiologie (Heidelberg, Germany)2026
Dual-respiratory-phase low-dose quantitative CT for assessing COPD severity.
Article in Radiologie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the ability of quantitative parameters derived from low-dose dual-respiratory-phase CT to differentiate the severity of chronic obstructive pulmonary disease (COPD). MATERIALS AND
methodsWe enrolled 100 COPD patients between October 2023 and October 2024. Inspiratory CT scans were performed using a standard-dose protocol, and expiratory scans were performed using a low-dose protocol. Images were reconstructed with 60% adaptive statistical iterative reconstruction (ASIR). Dual-respiratory-phase image registration was performed on a dedicated "Digital Lung" platform to quantify the following parameters: end-expiratory lung volume (LV
resultsQuantitative parameters, including LV
conclusionLow-dose expiratory CT combined with dual-respiratory-phase quantitative analysis provides reliable imaging biomarkers that correlate strongly with pulmonary function. The predictive model incorporating both fSAD% and Emph% demonstrates excellent diagnostic performance for assessing COPD severity and may serve as a noninvasive adjunct tool for disease stratification.
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