Evidence map›Paper›PMID 42888271›Full record

ArticleEJNMMI research2026

Matrix metalloproteinase imaging and survival prospects with aging in murine aortic aneurysm.

Mean Ghim, Onur Varli, Azmi A Ahmad, Afarin Neishabouri, Gunjan Kukreja, Zhengxing Zhang, Saalar Zarnegar, Nicholas Gangemi, Keshvad Hedayatyanfard, Jakub Toczek and 6 more

Abstract read
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In one paragraph

Article in EJNMMI research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mean GhimYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA.
Onur VarliYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA.
Azmi A AhmadYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA.
Afarin NeishabouriYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA.
Gunjan KukrejaYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA.
Zhengxing ZhangYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA.
Saalar ZarnegarYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA.
Nicholas GangemiYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA.
Keshvad HedayatyanfardYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA.
Jakub ToczekYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA.
Lingyun WangYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA.
Jiasheng ZhangYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA.
Chi LiuDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Yongjian LiuDepartment of Radiology, Washington University, St. Louis, MO, USA.
Robert J GroplerDepartment of Radiology, Washington University, St. Louis, MO, USA.
Mehran M SadeghiYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, Room 770G, New Haven, 06511, CT, USA. mehran.sadeghi@yale.edu.ORCID http://orcid.org/0000-0002-5074-3510

Funding

Training In Multi-modality Molecular & Translational Cardiovascular ImagingT32HL098069 · NHLBI · YALE UNIVERSITY · PI JAMES S DUNCAN, Georges El Fakhri · 2010 to 2026
$5.2M
PET Imaging of MMP Activation in AAA: First in-Human EvaluationR01AG065917 · NIA · YALE UNIVERSITY · PI GROPLER, ROBERT J., SADEGHI, MEHRAN M · 2020 to 2024
$3.3M
Molecular Imaging of Collagen Turnover in CardiomyopathyR01HL161746 · NHLBI · YALE UNIVERSITY · PI SADEGHI, MEHRAN M · 2022 to 2025
$3.1M
NHLBI NIH HHS R01HL161746NHLBI NIH HHS T32HL098069NIA NIH HHS R01AG065917U.S. Department of Veterans Affairs I0BX006098
6 · The paper itself

Abstract

backgroundMatrix metalloproteinases (MMPs) are elevated in aortic aneurysm (AA), where older age is a risk factor. The relationship among aging, aortic MMP activity, and AA development has not been systematically evaluated. This study leveraged MMP-targeted molecular imaging to investigate how aging affects aortic MMP activity, aneurysm development, and survival.

resultsAA development and animal survival were monitored for 28 days after Angiotensin (Ang)-II infusion in 8-10-week-old (young) and > 51-week-old (old) apolipoprotein E (Apoe)

conclusionsAging is associated with increased MMP activity along the aorta and worse AA survival. MMP-targeted molecular imaging provides insights regarding aneurysm survival prospects in this exploratory cohort. Combining MMP inhibitors and tracers may help prevent and track aneurysm growth, dissection, and rupture.

Indexed as

AgingAortic aneurysmMatrix metalloproteinasesMolecular imagingPET/CT

Identifiers

PMID42888271

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.