Trial report in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03011801 (Reducing Fetal Exposure to Maternal Depression to Improve Infant Risk Mechanisms), which is not on this map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing Fetal Exposure to Maternal Depression to Improve Infant Risk Mechanisms
TypeinterventionalSponsorUniversity of Illinois at Urbana-ChampaignRan2017 to 2024Enrolled234ConditionsDepressionArmsInterpersonal Therapy, Enhanced usual care
3 · Its place in the literature
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The record
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Catherine H DemersUniversity of Colorado Anschutz Medical Campus, Department of Psychiatry, Aurora, CO, USA. catherine.demers@cuanschutz.edu.ORCID http://orcid.org/0000-0001-5914-594X
Nancy K GroteUniversity of Washington, Department of Social Work, Seattle, WA, USA.
Elysia Poggi DavisUniversity of Denver, Department of Psychology, Denver, CO, USA. Elysia.Davis@du.edu.
Funding
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark D Shen · 2020 to 2026
$9.7M
Reducing Fetal Exposure to Maternal Depression to Improve Infant Risk MechanismsR01MH109662 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, HANKIN, BENJAMIN L · 2017 to 2021
$4.0M
Reducing maternal prenatal depression to improve child cardiovascular healthR01HL155744 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, DOOM, JENALEE RAE · 2021 to 2025
$3.6M
The Colorado Building Interdisciplinary Research Careers in Women's Health ProgramK12AR084226 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI JUDITH G. REGENSTEINER, Nanette F. Santoro · 2023 to 2026
$2.5M
Placental CRH and child cardiovascular disease risk and obesogenic eating behaviorsF32HL165844 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DEER, LILLYBELLE KUULEI · 2022 to 2024
$165k
Prenatal maternal depression exposure and infant neurocircuitry developmentF32MH125572 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DEMERS, CATHERINE · 2021 to 2021
$66k
U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) P50HD103573U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) F32HL165844U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL155744U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K12AR084226U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) F32MH125572U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH109662
6 · The paper itself
Abstract
Prenatal maternal depression may have intergenerational effects on offspring brain development, with potential socioemotional consequences. This observational follow-up study examines brain development and subsequent negative emotionality among 109 infants born to mothers participating in a randomized clinical trial (NCT03011801). In the prior trial, brief interpersonal psychotherapy significantly reduced prenatal depression symptoms and disorder as the published primary and secondary endpoints. Exploratory infant outcomes include hippocampal and amygdala volumes at 6 weeks and negative emotionality at 6 months. Here we show that infants of mothers randomized to interpersonal psychotherapy during pregnancy have lower right hippocampal volume than infants of mothers in the enhanced usual care group (p = .002, d = 0.62). No statistically significant group differences are observed in left hippocampal or amygdala volume. Smaller hippocampal volume predicts subsequent lower negative emotionality (r = 0.19, p = 0.045). In this study, a maternal prenatal depression intervention is associated with differences in infant brain development with implications for their subsequent emotional health.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Infant hippocampal and amygdala volume in an observational follow-up from a randomized clinical trial for maternal prenatal depression. · full record | OpenQuestion