Evidence map›Paper›PMID 42888207›Full record

ArticleJournal of exposure science & environmental epidemiology2026

Association between ambient temperature and thrombosis-related signaling lipids: Implications for early cardiovascular risk.

Haonan Li, Xi Chen, Yifan Xu, Teng Wang, Yuan Yao, Wu Chen, Jicheng Gong, Xinghua Qiu, Tong Zhu

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Article in Journal of exposure science & environmental epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Haonan Li *MEEKL-AERM, College of Environmental Sciences and Engineering, Center for Environment and Health, and Institute of Tibetan Plateau, Peking University, Beijing, China.ORCID http://orcid.org/0000-0003-1954-641X
Xi Chen *MEEKL-AERM, College of Environmental Sciences and Engineering, Center for Environment and Health, and Institute of Tibetan Plateau, Peking University, Beijing, China.
Yifan XuMEEKL-AERM, College of Environmental Sciences and Engineering, Center for Environment and Health, and Institute of Tibetan Plateau, Peking University, Beijing, China.
Teng WangMEEKL-AERM, College of Environmental Sciences and Engineering, Center for Environment and Health, and Institute of Tibetan Plateau, Peking University, Beijing, China.
Yuan YaoMEEKL-AERM, College of Environmental Sciences and Engineering, Center for Environment and Health, and Institute of Tibetan Plateau, Peking University, Beijing, China.
Wu ChenMEEKL-AERM, College of Environmental Sciences and Engineering, Center for Environment and Health, and Institute of Tibetan Plateau, Peking University, Beijing, China.
Jicheng GongMEEKL-AERM, College of Environmental Sciences and Engineering, Center for Environment and Health, and Institute of Tibetan Plateau, Peking University, Beijing, China.
Xinghua QiuMEEKL-AERM, College of Environmental Sciences and Engineering, Center for Environment and Health, and Institute of Tibetan Plateau, Peking University, Beijing, China.
Tong ZhuMEEKL-AERM, College of Environmental Sciences and Engineering, Center for Environment and Health, and Institute of Tibetan Plateau, Peking University, Beijing, China. tzhu@pku.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonoptimal temperatures significantly contribute to cardiovascular mortality, a burden expected to increase with climate change. Sensitive biomarkers for early cardiovascular risks remain scarce.

objectiveWe examined how thrombosis-related signaling lipids respond to ambient temperature, analyzing dose-response and lag patterns over a 30-day period, and assessed whether lipid changes mediate the association between temperature and thrombosis biomarkers using mediation analyses.

methodsWe conducted a prospective panel study of 112 participants (aged 42-80) in Beijing (2016-2017), each completing an average of 3.4 visits. Targeted lipidomics quantified 12 thrombosis-related signaling lipids, including thromboxane (Tx) B2, three lyso-platelet-activating factors (LysoPAFs), seven lysophosphatidic acids (LPAs), and sphingosine-1-phosphate (S1P). Ambient temperature data were obtained from the China National Meteorological Information Centre. Associations between cumulative temperature exposures (up to 30 days) and lipids were analyzed using generalized additive mixed models. Mediation analyses assessed whether lipid changes mediated temperature effects on soluble CD40 ligand (sCD40L), a sensitive biomarker for thrombotic disease.

resultsCold exposure was associated with significant decreases in TxB2, two LysoPAFs, and most LPAs (11-88% lower, median 45%, at a 30-day cumulative temperature of -0.8 °C vs. 18.7 °C). Heat exposure significantly increased all thrombosis-related lipids except LPA 20:3 (26% to 2,484% higher, median 65%, at a 30-day cumulative temperature of 27.7 °C vs. 18.7 °C), along with sCD40L (304% higher). Lipid effects were significant from 1-30 days of cumulative exposure, whereas heat-related sCD40L increases emerged after 6 days. LPA 18:0/18:1/20:4/22:6 and S1P mediated 12-32% of the heat-sCD40L association. SIGNIFICANCE: Higher ambient temperatures are associated with increased thrombosis-related lipids, which may act as early indicators of cardiovascular risks from heat exposure. IMPACT: This study quantified thrombosis-related signaling lipids across major lipid classes, i.e. eicosanoids (oxylipins), sphingolipids, and lysophospholipid, in a longitudinal panel study. Heat exposure significantly increased these signaling lipids, which responded to heat earlier than soluble CD40 ligand (sCD40L), a sensitive thrombotic biomarker. Mediation analysis revealed that these lipids mediate up to 32% of the heat-related thrombotic response. These findings suggest that thrombosis-related signaling lipids may serve as early indicators of heat-related cardiovascular risk, with implications for biomarker-based screening and climate change adaptation strategies.

Indexed as

AdaptionCardiometabolicMetabolomicsStressWarming climate

Identifiers

PMID42888207

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.