Evidence map›Paper›PMID 42887464›Full record

ArticleJACC. Advances2026

ANOCA Patients With Prior Obstructive Coronary Artery Disease and PCI Have Higher Odds of Epicardial Spasm.

Andreas Tzoumas, Timothy D Henry, Anibelky Almanzar, Sukhleen Kaur, Ellen Cravero, Namrita Ashokprabhu, Somesh Rai, Jane Carnesi, Claire Hanycz, Jenny Zhang and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Andreas TzoumasWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA; Division of Cardiovascular Health and Disease, University of Cincinnati Medical Center, Cincinnati, Ohio.
Timothy D HenryWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA; Division of Cardiovascular Health and Disease, University of Cincinnati Medical Center, Cincinnati, Ohio.
Anibelky AlmanzarDepartment of Internal Medicine, MetroHealth Medical Center, Cleveland, Ohio, USA.
Sukhleen KaurWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Ellen CraveroMinneapolis Heart Institute, Minneapolis, Minnesota, USA.
Namrita AshokprabhuWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Somesh RaiWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Jane CarnesiWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Claire HanyczWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Jenny ZhangWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Elnaz MahbubWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Evan LakhiaWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Jacob T DavisWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Ayushi MohanWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Kamryn WilsonWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Audrey BakerWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Philip ForrestWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Kaiya HansenWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Michelle HamstraWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Danielle N TappWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA.
Odayme QuesadaWomen's Heart Center, The Christ Hospital Heart and Vascular Institute, Cincinnati, Ohio, USA; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA; Division of Cardiovascular Health and Disease, University of Cincinnati Medical Center, Cincinnati, Ohio. Electronic address: Odayme.Quesada@thechristhospital.com.

Funding

Hypertensive Disorders of Pregnancy: Pathways to Future Cardiovascular DiseaseK23HL151867 · NHLBI · THE CHRIST HOSPITAL · PI QUESADA, ODAYME · 2020 to 2024
$799k
EMbArK: Empagliflozin Treatment of Ischemic with Non-Obstructive Coronary Arteries (INOCA)R01HL183368 · NHLBI · UNIVERSITY OF CINCINNATI · PI Odayme Quesada · 2026 to 2026
$734k
Identifying Inflammatory and Endothelial Mechanisms promoting Cardiac Deformation in Women with a History of PreeclampsiaR03HL177034 · NHLBI · THE CHRIST HOSPITAL · PI Odayme Quesada · 2025 to 2026
$198k
NHLBI NIH HHS K23 HL151867NHLBI NIH HHS R01 HL183368NHLBI NIH HHS R03 HL177034
6 · The paper itself

Abstract

backgroundUp to 50% of patients undergoing coronary angiography have angina with no obstructive coronary arteries (ANOCA). Among ANOCA patients, 2 distinct groups exist: patients with and without a history of prior obstructive coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI).

objectivesThis study aims to evaluate associations between history of prior obstructive CAD treated with PCI and coronary microvascular and vasomotor dysfunction endotypes in ANOCA patients.

methodsA prospective Coronary Microvascular and Vasomotor Dysfunction Registry of consecutive ANOCA patients undergoing invasive coronary functional testing (ICFT).

resultsAmong 624 ANOCA patients undergoing ICFT, 11% had prior obstructive CAD treated with PCI. ANOCA patients with prior obstructive CAD had a higher prevalence of males, were older, and had higher rates of cardiovascular risk factors. Prior obstructive CAD treated with PCI was associated with an 11-point lower Seattle Angina Questionnaire 7 summary score in unadjusted (β -11.0; 95% CI: -17.0 to -4.4; P = 0.001) and adjusted models. Patients with prior obstructive CAD treated with PCI had a higher prevalence of epicardial spasm by angiographic criteria (70% vs 34%; P < 0.001) and 4.55-fold higher odds of epicardial spasm in unadjusted (OR: 4.55; 95% CI: 2.65-8.07; P < 0.001) and adjusted models, with similar odds of coronary microvascular dysfunction.

conclusionsAmong ANOCA patients, those with prior obstructive CAD treated with PCI had over a 4-fold higher odds of epicardial spasm. These findings underscore the need for comprehensive ICFT in ANOCA patients with prior PCI.

Indexed as

ANOCACMVDICFTPCIspasm

Identifiers

PMID42887464
PMCPMC13696343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.