Amyloidosis and risk of psychiatric disorders-insights from a real-world nationwide registry.

Wei-Syun Hu, Po-Hsiang Liao, Cheng-Li Lin, Chih-Yang Huang

Abstract read

In one paragraph

Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wei-Syun HuSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung, Taiwan. Electronic address: weisyunhu@gmail.com.

Po-Hsiang LiaoCenter for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan, Taiwan.

Cheng-Li LinManagement Office for Health Data, China Medical University Hospital, Taichung, Taiwan.

Chih-Yang HuangDepartment of Precision Chinese Herbal Medicine and Molecular Medicine Research, E-Da Cancer Hospital, I-Shou University, Kaohsiung, Taiwan; Department of Precision Chinese Herbal Medicine and Molecular Medicine Research, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan; Superintendent's Office, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Office of Research & Development, Asia University, Taichung, Taiwan; Department of Nutritional Science, Fu Jen Catholic University, New Taipei, Taiwan. Electronic address: cyhuang@mail.cmu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis is a National Health Insurance (NHI) database research investigating the association between amyloidosis and psychiatric disorders risk.

methodsThe amyloidosis cohort was identified from insured individuals with amyloidosis, who were newly diagnosed from 2009 to 2019. Both cohorts were followed up and the subsequent psychiatric disorder was the major outcome event for the research. The multivariable model were used to examine the effect of amyloidosis and risk factor on the risk of developing psychiatric disorder.

resultsThe psychiatric disorder incidence was higher in the amyloidosis than in the comparison cohort (11.3 vs. 10.3 per 1000 person-years, crude HR = 1.10, 95% CI 1.02-1.19), with adjusted HR (aHR) of 1.26 (95% CI 1.16-1.36). After controlling for the confounders, amyloidosis cohort had a 1.38- fold higher risk of senile and pre-senile organic psychotic conditions (95% CI 1.22‒1.57), 1.26-fold higher risk of bipolar affective disorder (95% CI 1.10‒1.45), and 1.16-fold higher risk of other organic psychotic conditions than comparison cohort (95% CI 1.01-1.32).

conclusionsThe authors found that compared to a matched amyloidosis naïve cohort, psychiatric disorders risk was significantly higher in patients with amyloidosis. Among different psychiatric disorders, risks of senile and pre-senile organic psychotic conditions, bipolar affective disorder and other organic psychotic conditions were higher among people with amyloidosis.

Indexed as

AmyloidosisPsychiatric disorderRisk

Identifiers

PMID42887292

DOI10.1016/j.clinsp.2026.101208

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.