Evidence map›Paper›PMID 42886812›Full record

ArticleScience advances2026

TONSL/TONSOKU binding to histone H3.1 is required for DNA repair.

Hossein Davarinejad, Cloé Laflamme, Bianca Dupont, Sydney Lunde-Ingrey, Marcelo Muñoz, Monika Joshi, Sabina Sarvan, Hailey R Graham, Alex Ross, Joseph S Brunzelle and 5 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hossein DavarinejadOttawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.ORCID 0000-0002-6049-1492
Cloé LaflammeDepartment of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Université Laval, Québec, QC G1V 0A6 Canada.ORCID 0009-0007-1243-8711
Bianca DupontOttawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.ORCID 0009-0000-6913-0506
Sydney Lunde-IngreyOttawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.ORCID 0009-0006-9010-9799
Marcelo MuñozUniversity of Ottawa Heart Institute, Ottawa, ON K1Y 4W7, Canada.ORCID 0000-0001-7748-4996
Monika JoshiOttawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
Sabina SarvanOttawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.ORCID 0009-0004-9702-956X
Hailey R GrahamHuman Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada.ORCID 0009-0003-7507-4573
Alex RossUniversity of Ottawa Heart Institute, Ottawa, ON K1Y 4W7, Canada.ORCID 0000-0001-8013-4858
Joseph S BrunzelleFeinberg School of Medicine, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-9197-0018
Élise G LavoieOncology Division, CHU de Québec-Université Laval Research Center, Québec, QC G1J OJ9, Canada.ORCID 0000-0002-5836-4785
Emilio I AlarconOttawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.ORCID 0000-0001-5100-6179
Joey G SheffOttawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.ORCID 0000-0002-9269-6863
Amélie Fradet-TurcotteDepartment of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Université Laval, Québec, QC G1V 0A6 Canada.ORCID 0000-0002-5431-8650
Jean-François CoutureOttawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.ORCID 0000-0003-0385-4450

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In plants, TONSOKU (TSK) regulates heterochromatic DNA replication and genome stability by preferentially binding histone H3.1 over its close homolog, histone H3.3. The structure of this interaction showed that a shallow pocket in TSK's poly-tetratricopeptide repeat (TPR

Indexed as

DNA RepairHistonesAcetylationBinding SitesHumansMethylationProtein BindingProtein Processing, Post-TranslationalHistones

Identifiers

PMID42886812
PMCPMC13674474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.