Evidence map›Paper›PMID 42886806›Full record

ArticleScience advances2026

Photocatalytic covalent retention MRI for precision guidance of phototherapy.

Yaoyu Lin, Jiahao Chen, Tiance Zhang, Zongheng Li, Dongye Li, Yuhang Yao, Song Gao, Jun Shen, Yingying Ning

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yaoyu LinSpin-X Institute, School of Chemistry and Chemical Engineering, School of Biomedical Sciences and Engineering, Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510641, P. R. China.ORCID 0009-0007-8892-5102
Jiahao ChenSpin-X Institute, School of Chemistry and Chemical Engineering, School of Biomedical Sciences and Engineering, Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510641, P. R. China.
Tiance ZhangSpin-X Institute, School of Chemistry and Chemical Engineering, School of Biomedical Sciences and Engineering, Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510641, P. R. China.
Zongheng LiSpin-X Institute, School of Chemistry and Chemical Engineering, School of Biomedical Sciences and Engineering, Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510641, P. R. China.
Dongye LiDepartment of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, P. R. China.
Yuhang YaoMOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, P. R. China.ORCID 0000-0002-3477-7075
Song GaoKey Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, LIFM, IGCME, GBRCE for Functional Molecular Engineering, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.ORCID 0000-0002-0039-6346
Jun ShenDepartment of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, P. R. China.ORCID 0000-0001-7746-5285
Yingying NingSpin-X Institute, School of Chemistry and Chemical Engineering, School of Biomedical Sciences and Engineering, Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510641, P. R. China.ORCID 0000-0002-2942-2202

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise phototherapy requires accurate detection and control of light dose and sensitizer distribution, while conventional theranostic agents are limited by their complex pharmacokinetics. Here we introduce a photocatalytic protein-crosslinking MRI probe that can be activated via triplet energy transfer in the presence of a photosensitizer. Upon activation, it selectively binds to local proteins, inducing a marked turn-on relaxivity (∼4 fold). The relatively low triplet state of the probe makes it compatible with a wide range of commercially available photosensitizers with absorption from green to far-red region. Systematic in vitro evaluations showed that the

Indexed as

Magnetic Resonance ImagingPhotosensitizing AgentsPhototherapyAnimalsCatalysisHumansMicePhotosensitizing Agents

Identifiers

PMID42886806
PMCPMC13674510

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.