Evidence map›Paper›PMID 42886800›Full record

ArticleScience advances2026

Therapeutic-scale CAR-NK microrobots with programmable swarm navigation for targeted solid tumor therapy.

Zhiguang Wu, Yalin Wang, Hongyue Zhang, Xinjian Fan, Mingtong Li, Zesheng Li, Gongzi Zhang, Jialin Wang, Yumeng Lu, Hongda Wang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Zhiguang WuSchool of School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China.ORCID 0000-0002-0570-0757
Yalin WangSchool of School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China.ORCID 0009-0006-1855-9306
Hongyue ZhangSchool of School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China.ORCID 0000-0001-5354-3525
Xinjian FanSchool of Mechanical and Electrical Engineering, Soochow University, Suzhou 215131, China.ORCID 0000-0002-8854-1287
Mingtong LiPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart 70569, Germany.ORCID 0000-0002-1685-6052
Zesheng LiSchool of School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China.ORCID 0000-0002-3392-8812
Gongzi ZhangChina Department of Orthopedics, Chinese PLA General Hospital, Beijing 100141, China.ORCID 0000-0002-6955-7021
Jialin WangDepartment of Science, Computer Science, University of Alberta, Edmonton T6G 2R3, Canada.ORCID 0009-0000-0343-577X
Yumeng LuSchool of School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China.ORCID 0009-0004-9229-1008
Hongda WangSchool of School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China.ORCID 0009-0009-1587-9437
Yuxin JiaDepartment of Mathematics, Imperial College London, London SW7 2AZ, UK.ORCID 0009-0009-0004-2917
Hongri GuDivision of Integrated System and Design, Hong Kong University of Science and Technology, Hong Kong 999077, China.ORCID 0000-0002-6396-3408
He TanComprehensive Cancer Centre, Denmark Hill Campus, King's College London, London SE5 9NU, UK.ORCID 0009-0000-6046-2811
Jiawei TianSchool of Future Technology, Harbin Institute of Technology, Harbin 150001, China.
Ximing SunSchool of Future Technology, Harbin Institute of Technology, Harbin 150001, China.ORCID 0009-0003-3541-5281
Hui XieState Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin 150001, China.ORCID 0000-0003-4299-2776
Lihai ZhangChina Department of Orthopedics, Chinese PLA General Hospital, Beijing 100141, China.ORCID 0000-0003-3172-6309
Metin SittiPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart 70569, Germany.ORCID 0000-0001-8249-3854
Jie ZhaoState Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin 150001, China.ORCID 0000-0002-6086-9387

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An urgent requirement in chimeric antigen receptor (CAR) immune cell therapy [e.g., CAR-natural killer (NK) cells] for solid tumors is to engineer the cells for precise tumor targeting. Meanwhile, medical microrobots can be navigated toward specific target sites using external magnetic fields. Here, by bridging these approaches, we turn CAR-NK cells into magnetic biohybrid microrobots (CAR-NK microrobots) that achieve controllable long-distance targeted navigation at therapeutic doses (∼10

Indexed as

Immunotherapy, AdoptiveKiller Cells, NaturalNeoplasmsReceptors, Chimeric AntigenRoboticsAnimalsHumansMagnetic FieldsMiceReceptors, Chimeric Antigen

Identifiers

PMID42886800
PMCPMC13674493

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.