Evidence map›Paper›PMID 42886795›Full record

ArticleScience advances2026

Muscle stem cells produce a protective Fibrillin-1 matrix to prevent precocious activation.

Eleni Chrysostomou, Oussama Smail, Artemis Vlachopoulou, Takuto Hayashi, Nicolas Tcheng, Nicol Voermans, Dieter P Reinhardt, Frederic Relaix, Philippos Mourikis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eleni ChrysostomouUniversité Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades (INEM), 75015 Paris, France.ORCID 0000-0003-2455-6321
Oussama SmailUniv Paris Est Créteil, INSERM, IMRB, EnvA, APHP, EFS, F-94010 Créteil, France.ORCID 0009-0002-0678-5489
Artemis VlachopoulouUniversité Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades (INEM), 75015 Paris, France.ORCID 0009-0009-4804-3935
Takuto HayashiUniversité Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades (INEM), 75015 Paris, France.ORCID 0009-0007-6313-4347
Nicolas TchengFaculté de Médecine Paris Descartes, 15 rue de l'École de médecine, 75006 Paris, France.
Nicol VoermansDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands.ORCID 0000-0002-5837-7295
Dieter P ReinhardtFaculty of Medicine and Health Sciences, Department of Anatomy and Cell Biology, McGill University, Montréal, QC, Canada.ORCID 0000-0001-6535-9872
Frederic RelaixUniv Paris Est Créteil, INSERM, IMRB, EnvA, APHP, EFS, F-94010 Créteil, France.ORCID 0000-0003-1270-1472
Philippos MourikisUniversité Paris Cité, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades (INEM), 75015 Paris, France.ORCID 0000-0003-3164-7109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diverse biological mechanisms regulate muscle stem cell quiescence, including inhibition of differentiation, adhesion, and translational control. Here, we identify the matrix glycoprotein Fibrillin-1 (FBN1) as a Notch-regulated, cell-autonomous effector, essential for maintaining quiescence. Known for its causal role in Marfan syndrome (MFS), our work positions FBN1 as a critical niche component that protects muscle stem cells from aberrant growth factor signaling. Targeted deletion of

Indexed as

Extracellular MatrixFibrillin-1Stem CellsAdipokinesAnimalsCell DifferentiationHumansMarfan SyndromeMiceMuscle, SkeletalSatellite Cells, Skeletal MuscleSignal TransductionTransforming Growth Factor betaAdipokinesFBN1 protein, humanFbn1 protein, mouseFibrillin-1Transforming Growth Factor beta

Identifiers

PMID42886795
PMCPMC13674515

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.