ArticleScience advances2026
A caprine mammary infection model for highly pathogenic avian influenza H5N1.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Highly pathogenic avian influenza (HPAI) H5N1 virus spillover into dairy cows represents the emergence of a mammalian host capable of sustaining a panzootic and creates a transmission pathway to humans. HPAI research involving dairy cows is constrained by the space requirements needed to house large animals in high biocontainment. A small ruminant model would enable larger sample sizes while reducing costs, improving safety, and lowering logistical barriers to conduct research. Here, we establish dairy goats as a model for HPAI mammary infection. Intramammary inoculation with HPAI H5N1 genotype D1.1 and genotype B3.13 resulted in acute mastitis, decreased milk yield, and high virus shedding in milk. Parenteral vaccination with an inactivated virus induced antigen-specific antibodies in blood and milk, reduced clinical disease, limited virus shedding in milk, and mitigated milk production losses. HPAI H5N1 disease dynamics in dairy cows can be recapitulated in dairy goats, providing a relevant model for investigating pathogenesis and for supporting the development of control strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.