In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Jun TamuraDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba City, Chiba 260-8670, Japan.ORCID 0000-0002-1024-6763 Shigeru TanakaDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba City, Chiba 260-8670, Japan.ORCID 0000-0002-8466-110X Keishi EtoriDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba City, Chiba 260-8670, Japan.ORCID 0000-0002-2353-6719 Daisuke HashibaDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba City, Chiba 260-8670, Japan.
Shuhei KamedaDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba City, Chiba 260-8670, Japan.ORCID 0009-0001-8193-9778 Atsuko TomikawaDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba City, Chiba 260-8670, Japan.
Ryo KikuchiDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba City, Chiba 260-8670, Japan.
Tatsuro TakahashiDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba City, Chiba 260-8670, Japan.
Aiko SakuDepartment of Allergy and Rheumatology, International University of Health and Welfare Narita Hospital, 852 Hatakeda, Narita City, Chiba 286-0048, Japan.ORCID 0000-0002-9632-5744 Hirotoshi KawashimaDepartment of Allergy and Rheumatology, International University of Health and Welfare Narita Hospital, 852 Hatakeda, Narita City, Chiba 286-0048, Japan.ORCID 0000-0001-7364-127X Junichi NakamuraDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba City, Chiba 260-8670, Japan.ORCID 0000-0003-4005-8832 Seiji OhtoriDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba City, Chiba 260-8670, Japan.ORCID 0000-0001-5738-6184 Shin-Ichiro KagamiResearch Center for Allergy and Clinical Immunology, Asahi General Hospital, 1326 I, Asahi City, Chiba 289-2511, Japan.ORCID 0000-0001-9439-8918 Koichi HiroseDepartment of Allergy and Rheumatology, International University of Health and Welfare Narita Hospital, 852 Hatakeda, Narita City, Chiba 286-0048, Japan.ORCID 0000-0001-7498-9630 Hiroshi NakajimaDepartment of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba City, Chiba 260-8670, Japan.ORCID 0000-0001-8595-9381 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Psychological stress affects the immune system and exacerbates autoimmune diseases such as rheumatoid arthritis (RA), but the mechanisms underlying tissue inflammation during remission remain unclear. Here, we show that tube restraint stress exacerbates joint inflammation in a murine arthritis model during remission. This exacerbation required interleukin-6 (IL-6) produced by brown adipose tissue (BAT) following sympathetic activation. Fibroblast-like synoviocytes expressing the IL-6 receptor subunit gp130 were critical mediators, as IL-6 stimulated these cells to produce the neutrophil chemoattractant CXCL1. Pharmacological blockade of the β3-adrenergic receptor significantly attenuated stress-induced arthritis flares. In patients with RA, carriers of the hypofunctional Trp64Arg variant of
Indexed as
Arthritis, RheumatoidFibroblastsInterleukin-6Stress, PsychologicalSynoviocytesAnimalsArthritis, ExperimentalChemokine CXCL1Disease Models, AnimalHumansMaleMiceReceptors, Adrenergic, beta-3Chemokine CXCL1Interleukin-6Receptors, Adrenergic, beta-3
Identifiers
PMID42886783
PMCPMC13674482
What OpenQuestion holds
Textmetadata
Read underepoch 390