Evidence map›Paper›PMID 42886780›Full record

ArticleScience advances2026

Phosphorylation by CaMKIV regulates the transcriptional repressor activity and half-life of REST/NRSF.

Hanako Tsushima Semini, Beatrice Corradi, Caterina Canevari, Dmytro Shmal, Martina Chiacchiaretta, Nara Liessi, Andrea Di Fonzo, Emanuele Carminati, Andrea Armirotti, Anna Fassio and 3 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hanako Tsushima SeminiCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi, 10, 16132 Genova, Italy.ORCID 0000-0003-3179-4301
Beatrice CorradiCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi, 10, 16132 Genova, Italy.ORCID 0000-0002-9510-9388
Caterina CanevariCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi, 10, 16132 Genova, Italy.ORCID 0009-0004-8931-2680
Dmytro ShmalCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi, 10, 16132 Genova, Italy.
Martina ChiacchiarettaCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi, 10, 16132 Genova, Italy.ORCID 0000-0003-1890-3091
Nara LiessiAnalytical Chemistry Facility, Istituto Italiano di Tecnologia, 16163 Genoa, Italy.ORCID 0000-0002-2112-4753
Andrea Di FonzoAnalytical Chemistry Facility, Istituto Italiano di Tecnologia, 16163 Genoa, Italy.ORCID 0009-0001-0495-9978
Emanuele CarminatiCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi, 10, 16132 Genova, Italy.
Andrea ArmirottiAnalytical Chemistry Facility, Istituto Italiano di Tecnologia, 16163 Genoa, Italy.ORCID 0000-0002-3766-8755
Anna FassioDepartment of Experimental Medicine, Università degli Studi di Genova, Viale Benedetto XV 3, 16132 Genova, Italy.ORCID 0000-0002-8801-038X
Luca MaraglianoCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi, 10, 16132 Genova, Italy.ORCID 0000-0002-5705-6967
Anna RocchiCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi, 10, 16132 Genova, Italy.
Fabio BenfenatiCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi, 10, 16132 Genova, Italy.ORCID 0000-0002-0653-8368

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repressor Element-1 (RE1)-Silencing Transcription Factor (REST) homeostatically regulates neural activity by repressing a large cluster of neural genes. However, whether REST can be regulated by calcium(2+) (Ca

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase Type 4Repressor ProteinsTranscription, GeneticAnimalsHEK293 CellsHumansMolecular Dynamics SimulationPhosphorylationProtein BindingRE1-Silencing Transcription FactorCalcium-Calmodulin-Dependent Protein Kinase Type 4RE1-Silencing Transcription FactorRepressor Proteins

Identifiers

PMID42886780
PMCPMC13674487

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.