Evidence map›Paper›PMID 42886774›Full record

ArticleScience advances2026

Suppression of meiotic double-strand break formation in somatic cells by DREAM factors TCX5/6 maintains genome stability.

Yuxuan Guo, Xinwen Zheng, Tianyi Wang, Jinchao Li, Cong Wang, Chenjiang You, Xin-Jian He, Arp Schnittger, Ji Qi, Jun Wang and 1 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuxuan GuoState Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China.ORCID 0009-0005-4591-5110
Xinwen ZhengState Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China.ORCID 0009-0008-7622-3936
Tianyi WangState Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China.ORCID 0009-0003-9302-211X
Jinchao LiState Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China.
Cong WangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0002-1647-1072
Chenjiang YouGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0002-9935-1892
Xin-Jian HeNational Institute of Biological Sciences, Beijing 102206, China.ORCID 0000-0002-2878-7461
Arp SchnittgerDepartment of Developmental Biology, University of Hamburg, Hamburg 22609, Germany.ORCID 0000-0001-7067-0091
Ji QiState Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China.ORCID 0000-0001-7135-0524
Jun WangState Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China.ORCID 0000-0001-8872-4131
Yingxiang WangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0001-6085-5615

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meiotic recombination in reproductive cells is initiated by DNA double-strand breaks (DSBs) and requires the expression of meiosis-specific genes, yet how the transcription of those genes is regulated in either meiotic or somatic cells remains unclear. Here, using a representative meiosis-specific

Indexed as

DNA Breaks, Double-StrandedGenomic InstabilityMeiosisRepressor ProteinsAnimalsCell Cycle ProteinsEndodeoxyribonucleasesHistonesMeiotic Recombination Protein SPO11Promoter Regions, GeneticCell Cycle ProteinsEndodeoxyribonucleasesHistonesMeiotic Recombination Protein SPO11Repressor Proteins

Identifiers

PMID42886774
PMCPMC13674478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.