Evidence map›Paper›PMID 42886694›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A muscle-enriched mitochondrial protein regulates postnatal heart growth through mitonuclear ubiquinone-PPAR signaling.

Kentaro Hirose, Xiaoxin Chen, Chakrapani Kalyanaraman, Mark T Waddingham, Makoto Nakamura, Feng Zhang, Christina Chen, Shun Yao, Steven Chang, Hongyao Yu and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Kentaro Hirose *Cardiovascular Research Institute, University of California, San Francisco, CA 94158.ORCID 0000-0002-0634-3173
Xiaoxin Chen *Cardiovascular Research Institute, University of California, San Francisco, CA 94158.ORCID 0000-0003-3092-7010
Chakrapani KalyanaramanDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Mark T WaddinghamDepartment of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita 564-8565, Osaka, Japan.ORCID 0000-0002-0058-9455
Makoto NakamuraCardiovascular Research Institute, University of California, San Francisco, CA 94158.ORCID 0000-0002-5527-5074
Feng ZhangCardiovascular Research Institute, University of California, San Francisco, CA 94158.
Christina ChenCardiovascular Research Institute, University of California, San Francisco, CA 94158.
Shun YaoCardiovascular Research Institute, University of California, San Francisco, CA 94158.ORCID 0009-0008-8530-0526
Steven ChangCardiovascular Research Institute, University of California, San Francisco, CA 94158.ORCID 0009-0006-0807-0021
Hongyao YuEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Jiajia WangEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.ORCID 0009-0000-5123-7989
Emanuele BarcaDepartment of Neurology, Columbia University Medical Center, New York, NY 10032.
Haruko NakanoDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095.
Austin HsuGladstone Institutes, San Francisco, CA 94158.ORCID 0000-0002-4361-4358
Sheamin KhyeamCardiovascular Research Institute, University of California, San Francisco, CA 94158.
Sara Gonzalez OrtegaCardiovascular Research Institute, University of California, San Francisco, CA 94158.ORCID 0000-0001-9632-5069
Kazuki TajimaEli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94158.
Takeshi YoneshiroEli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94158.
Hao ZhangCardiovascular Research Institute, University of California, San Francisco, CA 94158.
Arun PadmanabhanCardiovascular Research Institute, University of California, San Francisco, CA 94158.
Shingo KajimuraEli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94158.ORCID 0000-0003-0672-5910
Saptarsi HaldarGladstone Institutes, San Francisco, CA 94158.
Atsushi NakanoDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095.
Masatoshi MuraiDivision of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Yoshitaka FujiharaDepartment of Advanced Medical Technologies, National Cerebral and Cardiovascular Center, Suita, Osaka 564-8565, Japan.ORCID 0000-0001-8332-3507
Kinya OtsuOffice of the President, National Cerebral and Cardiovascular Center, Suita, Osaka 564-8565, Japan.
Catarina M QuinziiDepartment of Neurology, Columbia University Medical Center, New York, NY 10032.ORCID 0000-0003-3819-1298
Matthew P JacobsonDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Guang HuEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
James T PearsonDepartment of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita 564-8565, Osaka, Japan.ORCID 0000-0002-3318-5406
Guo N HuangCardiovascular Research Institute, University of California, San Francisco, CA 94158.ORCID 0000-0002-4335-9123

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased mitochondrial biogenesis and aerobic respiration in postnatal mammalian organs are essential for adaptation to extrauterine life, yet the functions of many tissue-enriched, developmentally regulated mitochondrial proteins remain poorly defined. By integrating mitochondrial proteome annotations with mouse and human transcriptomic datasets, we identified Coenzyme Q10a (Coq10a), a striated muscle-enriched mitochondrial protein, as a regulator of postnatal cardiac growth. Coq10a, the mammalian homolog of the yeast ubiquinone-binding protein Coq10p, is highly induced in the heart after birth through thyroid hormone-, Nkx2.5-, and Tbx5-dependent regulation. To define its physiological function, we generated three independent

Indexed as

HeartMitochondrial ProteinsPPAR alphaUbiquinoneAnimalsCardiomegalyHumansMiceMice, KnockoutMyocardiumMyocytes, CardiacSignal Transductioncoenzyme Q10Mitochondrial ProteinsPPAR alphaUbiquinonecardiac hypertrophyCoq10amitochondriaPPAR signalingubiquinone

Identifiers

PMID42886694
PMCPMC13684178

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.