ArticleProceedings of the National Academy of Sciences of the United States of America2026
Omega-3 fatty acids reprogram tumor-associated macrophage cytokine signaling and suppress pancreatic cancer growth.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Omega-3 fatty acids reprogram tumor-associated macrophage cytokine signaling and suppress pancreatic cancer growth.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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22 authors.
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Abstract
Dietary polyunsaturated fatty acids (PUFAs) shape inflammatory signaling within the pancreatic tumor microenvironment (TME), but the cellular mechanisms underlying their effects on tumor progression remain unclear. Using orthotopic models of pancreatic ductal adenocarcinoma (PDAC), we show that omega-3 (n-3) and omega-6 (n-6) PUFAs are differentially incorporated into tumor lipid pools, generating spatially heterogeneous lipid microenvironments. While an n-6-enriched diet accelerated PDAC growth, an n-3-enriched diet suppressed tumor growth in a T cell-independent manner. Examining inflammatory effects in PDAC tumors, the n-3 PUFA-enriched diet reduced pro-inflammatory cytokines, including IL-6 family members, and single-cell and spatial analyses identified tumor-associated macrophages (TAMs) as the primary diet-responsive population. Indeed, selective conversion of n-6 to n-3 fatty acids within myeloid cells using an inducible
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