Evidence map›Paper›PMID 42886684›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Loss of Acid Ceramidase in Myeloid Cells Protects From Chronic Colitis in IL10-Deficient Mice.

Keila S Espinoza, Brandon K Dahl, Ella M Ryan, Mary R Gordon, Chelsea L Doll, Marilyn T Marron, Cameron A Beard, Pujarini D Dey, David G Besselsen, Richard J Simpson and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Keila S EspinozaPhysiological Sciences GIDP, University of Arizona, Tucson, Arizona, USA.ORCID https://orcid.org/0000-0001-8514-1600
Brandon K DahlSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA.
Ella M RyanUniversity of Arizona College of Medicine, University of Arizona, Tucson, Arizona, USA.
Mary R GordonUniversity of Arizona College of Science, University of Arizona, Tucson, Arizona, USA.
Chelsea L DollSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA.ORCID https://orcid.org/0009-0000-5987-1837
Marilyn T MarronSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA.
Cameron A BeardSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA.
Pujarini D DeyDepartment of Pediatrics, Steele Children's Research Center, Daniel Cracchiolo Institute for Pediatric Autoimmune Disease Research, University of Arizona Health Sciences Center, Tucson, Arizona, USA.
David G BesselsenUniversity Animal Care, The University of Arizona, Tucson, Arizona, USA.
Richard J SimpsonPhysiological Sciences GIDP, University of Arizona, Tucson, Arizona, USA.ORCID https://orcid.org/0000-0002-7064-6881
Justin M SniderSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA.
Justin E WilsonUniversity of Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.ORCID https://orcid.org/0000-0002-2803-3280
Pawel R KielaPhysiological Sciences GIDP, University of Arizona, Tucson, Arizona, USA.
Ashley J SniderPhysiological Sciences GIDP, University of Arizona, Tucson, Arizona, USA.

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
PARP1 and PARylation as novel effectors of gut inflammationR01DK136240 · NIDDK · UNIVERSITY OF ARIZONA · PI Fayez Khalaf Ghishan, Pawel R Kiela · 2023 to 2026
$2.6M
Role for myeloid acid ceramidase in colon inflammation and cancerR01DK132079 · NIDDK · UNIVERSITY OF ARIZONA · PI Ashley Jones Snider · 2022 to 2026
$1.6M
Impact of AIM2 on Intestinal Stem Cell Differentiation During InflammationR01DK141491 · NIDDK · UNIVERSITY OF ARIZONA · PI Justin Ethan Wilson · 2025 to 2026
$1.1M
The Impact of Acid Ceramidase in Myeloid Cells on Intestinal InflammationF31DK145020 · NIDDK · UNIVERSITY OF ARIZONA · PI Keila Espinoza Vellutato · 2026 to 2026
$50k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) F31 DK145020HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01 DK132079HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01 DK136240HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01 DK141491HHS | NIH | NCI | Division of Cancer Prevention, National Cancer Institute (DCP, NCI) P30 CA023074NCI NIH HHS P30 CA023074NIDDK NIH HHS F31 DK145020NIDDK NIH HHS R01 DK132079NIDDK NIH HHS R01 DK136240NIDDK NIH HHS R01 DK141491
6 · The paper itself

Abstract

Patients with inflammatory bowel disease exhibit elevated expression of acid ceramidase (AC), an enzyme in sphingolipid metabolism. Recent studies have shown that myeloid cells contribute to the elevated expression of AC, such that the conditional loss in these cell types protects from acute colitis. We crossed conditional ASAH1 LyzM

Indexed as

Acid CeramidaseColitisInterleukin-10Myeloid CellsAnimalsChronic DiseaseColonInflammatory Bowel DiseasesLysophospholipidsMiceMice, Inbred C57BLMice, KnockoutSphingosineTh1 CellsAcid CeramidaseAsah1 protein, mouseIL10 protein, mouseInterleukin-10LysophospholipidsSphingosinesphingosine 1-phosphateacid ceramidasecolitisinflammatory bowel diseasemacrophagesphingolipid

Identifiers

PMID42886684
PMCPMC13674723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.