ArticleBrain and behavior2026
Procedural Learning and Retention in Older Subjects: The Contribution of Sensorimotor and Premotor Cortex.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo investigate the neurobiological basis of procedural learning and retention of motor memories in aging.
methodWe used a modified serial reaction time (SRT) task with feedback in two age groups: young (n = 18, 24.9 ± 3.9 years, range: 18-32 years) and older (n = 19, 63.5 ± 5.1 years, range: 54-73 years) healthy participants. We assessed procedural learning while participants underwent functional magnetic resonance imaging (fMRI, Day 1). On the following day, we assessed retention behaviorally outside the scanner. FINDING: Both groups showed significant procedural learning (p < 0.001) and retention (p < 0.05). Notably, retention was enhanced in older compared to younger adults (p < 0.01), even after normalizing the reaction time (RT) gains to individual RT (p < 0.05). Functional imaging revealed more robust recruitment of the left sensorimotor cortex (SM1) during procedural learning in older participants. Besides, left premotor cortex activity during procedural learning predicted retention in both age groups.
conclusionOur data show that procedural learning was preserved in healthy older adults. At the same time, retention was even enhanced in healthy older adults. These processes were associated with activation changes in the contralateral sensorimotor and premotor cortices.
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